Structure
Sitaxsentan Biochemical
Sitaxsentan
Purity
>98% (HPLC)
Synonyms
Sitaxsentan; IPI-1040; Sitaxentan; TBC-11251; Sitaxsentan biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Endothelin Receptor
Receptor
Endothelin Receptor
Chemical Name
3-Thiophenesulfonamide, N-(4-chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1, 3-benzodioxol-5-yl)acetyl]
SMILES
CC1=CC2=C(C=C1CC(=O)C3=C(C=CS3)S(=O)(=O)NC4=C(C(=NO4)C)Cl)OCO2
Molecular Formula
C18H15ClN2O6S2
CAS Number
184036-34-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Sitaxsentan biochemical
A potent, long acting, orally active, selective ETA receptor antagonist that binds competitively to human ETA receptor with Ki of 0.43nM, IC50 of 1.4nM; dispalys >5,000-fold selectivity over ETB receptors; inhibits ET1-induced stimulation of phosphoinositide turnover with Ki of 0.686nM, and pA2 of 8.0; excellent PK profile and oral bioavailability. Hypertension Withdrawn
Product Categories/Family for Sitaxsentan biochemical
References
1. Wu C, et al. J Med Chem. 1997 May 23; 40 (11):1690-7.
2. Wanebo JE, et al. Neurosurgery. 1998 Dec; 43 (6):1409-17; discussion 1417-8.
3. Tilton RG, et al. Pulm Pharmacol Ther. 2000; 13 (2):87-97.
2. Wanebo JE, et al. Neurosurgery. 1998 Dec; 43 (6):1409-17; discussion 1417-8.
3. Tilton RG, et al. Pulm Pharmacol Ther. 2000; 13 (2):87-97.
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Product Notes
The Sitaxsentan (Catalog #AAA3602843) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Sitaxsentan, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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