Testing Data
Rabbit anti-Human HAT-3 Polyclonal Antibody | anti-HAT-3 antibody
HAT-3 Antibody
Appearance: Colorless liquid
Shelf Life: 12 months
Testing Data
Testing Data
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the MOZ, YBFR2, SAS2, TIP60 family of histone acetyltransferases. The protein is composed of a nuclear localization domain, a double C2H2 zinc finger domain that binds to acetylated histone tails, a histone acetyl-transferase domain, a glutamate/aspartate-rich region, and a serine- and methionine-rich transactivation domain. It is part of a complex that acetylates lysine-9 residues in histone 3, and in addition, it acts as a co-activator for several transcription factors. Allelic variants of this gene are associated with autosomal dominant mental retardation-32. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Uniprot Description
MYST3: Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Chromosomal aberrations involving KAT6A may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with CREBBP; translocation t(8;22)(p11;q13) with EP300. KAT6A- CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Inversion inv(8)(p11;q13) generates the KAT6A-NCOA2 oncogene, which consists of the N-terminal part of KAT6A and the C-terminal part of NCOA2/TIF2. KAT6A-NCOA2 binds to CREBBP and disrupts its function in transcription activation. A chromosomal aberration involving KAT6A is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with ASXL2 generates a KAT6A-ASXL2 fusion protein. Belongs to the MYST (SAS/MOZ) family.
Protein type: Oncoprotein; Nucleolus; EC 2.3.1.48; Acetyltransferase
Chromosomal Location of Human Ortholog: 8p11
Cellular Component: nucleoplasm; Golgi apparatus; PML body; nucleolus; nucleosome; nucleus
Molecular Function: protein binding; histone acetyltransferase activity; DNA binding; zinc ion binding; transcription coactivator activity; acetyltransferase activity; chromatin binding; transcription factor binding
Biological Process: heart morphogenesis; nucleosome assembly; establishment and/or maintenance of chromatin architecture; protein amino acid acetylation; transcription, DNA-dependent; embryonic hemopoiesis; somatic stem cell maintenance; negative regulation of transcription factor activity; positive regulation of transcription, DNA-dependent; myeloid cell differentiation; histone acetylation; negative regulation of transcription, DNA-dependent; DNA packaging
Disease: Mental Retardation, Autosomal Dominant 32
Research Articles on HAT-3
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Product Notes
The HAT-3 kat6a (Catalog #AAA841155) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The HAT-3 Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's HAT-3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Western blotting (2-6 ug/ml). However, the optimal concentrations should be determined individually. Jurkat cell lysate can be used as a positive control. The antibody recognizes 220 kDa human HAT-3. A 50 kDa unknown band can also be detected. Reactivity to other species has not been determined. Researchers should empirically determine the suitability of the HAT-3 kat6a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HAT-3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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