Rabbit anti-Human GRPR Polyclonal Antibody | anti-GRPR antibody

GRPR, ID (GRPR, Gastrin-releasing peptide receptor, GRP-preferring bombesin receptor) (Biotin)

Cat. Num. AAA6304549

• Gene Names: GRPR; BB2
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: GRPR; Polyclonal Antibody; ID (GRPR; Gastrin-releasing peptide receptor; GRP-preferring bombesin receptor) (Biotin); GRP-preferring bombesin receptor; anti-GRPR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GRPR.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-GRPR antibody: Immunohistochemistry (IHC) Paraffin, ELISA (EIA)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 123-152 in the central region of human GRPR. Species sequence homology: mouse and rat
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS648020. GRPR (arrow) was detected usingMBS648020.)

Testing Data

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Testing Data

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Product Categories/Family for anti-GRPR antibody

Antibodies; Receptors

References

1. Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010). 2. Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009). 3. Chao, C., et al. J. Surg. Res. 156(1):26-31(2009). 4. Ananias, H.J., et al. Prostate 69(10):1101-1108(2009). 5. Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 232185
• NCBI GeneID: 2925
• UniProt Accession #: P30550; B2R910; AAB27329
• Molecular Weight: 384
• NCBI Official Full Name: Gastrin-releasing peptide receptor
• NCBI Official Synonym Full Names: gastrin-releasing peptide receptor
• NCBI Official Symbol: GRPR
• NCBI Official Synonym Symbols: BB2
• NCBI Protein Information: gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor
• UniProt Protein Name: Gastrin-releasing peptide receptor
• Protein Family: Gastrin-releasing peptide receptor
• UniProt Gene Name: GRPR
• UniProt Synonym Gene Names: GRP-R
• UniProt Entry Name: GRPR_HUMAN

NCBI Description

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: bombesin receptor activity; peptide receptor activity, G-protein coupled

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation