Rabbit anti-Human GRPR Polyclonal Antibody | anti-GRPR antibody

GRPR, ID (GRPR, Gastrin-releasing peptide receptor, GRP-preferring bombesin receptor) (MaxLight 405)

Cat. Num. AAA6304552

• Gene Names: GRPR; BB2
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified by Protein A and Peptide Affinity Chromatography.
• Synonyms: GRPR; Polyclonal Antibody; ID (GRPR; Gastrin-releasing peptide receptor; GRP-preferring bombesin receptor) (MaxLight 405); GRP-preferring bombesin receptor; anti-GRPR antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GRPR.
• Purity/Purification: Purified by Protein A and Peptide Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight405.

• Applicable Applications for anti-GRPR antibody: Immunohistochemistry (IHC) Paraffin, FLISA
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 123-152 in the central region of human GRPR. Species sequence homology: mouse and rat
• Conjugate: MaxLight405
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight405 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(Western Blot analysis in HL-60 cell line lysates (35ug/lane) usingMBS648020. GRPR (arrow) was detected usingMBS648020.)

Product Categories/Family for anti-GRPR antibody

Antibodies; Receptors

References

1. Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010). 2. Chapuis, J., et al. Mol. Psychiatry 14(11):1004-1016(2009). 3. Chao, C., et al. J. Surg. Res. 156(1):26-31(2009). 4. Ananias, H.J., et al. Prostate 69(10):1101-1108(2009). 5. Fleischmann, A., et al. Endocr. Relat. Cancer 16(2):623-633(2009).

NCBI and Uniprot Product Information

• NCBI GI #: 232185
• NCBI GeneID: 2925
• UniProt Accession #: P30550; B2R910; AAB27329
• Molecular Weight: 384
• NCBI Official Full Name: Gastrin-releasing peptide receptor
• NCBI Official Synonym Full Names: gastrin-releasing peptide receptor
• NCBI Official Symbol: GRPR
• NCBI Official Synonym Symbols: BB2
• NCBI Protein Information: gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor
• UniProt Protein Name: Gastrin-releasing peptide receptor
• Protein Family: Gastrin-releasing peptide receptor
• UniProt Gene Name: GRPR
• UniProt Synonym Gene Names: GRP-R
• UniProt Entry Name: GRPR_HUMAN

NCBI Description

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]

Uniprot Description

GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: bombesin receptor activity; peptide receptor activity, G-protein coupled

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation