Western Blot (WB)
(Anti-GHR antibody, MBS175741, Western blottingAll lanes: Anti GHR (MBS175741) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Kidney Tissue Lysate at 50ugLane 3: Rat Spleen Tissue Lysate at 50ugLane 4: Rat Intestine Tissue Lysate at 50ugLane 5: Mouse Spleen Tissue Lysate at 50ugLane 6: Mouse Testis Tissue Lysate at 50ugLane 7: Mouse Liver Tissue Lysate at 50ugLane 8: Mouse Kidney Tissue Lysate at 50ugLane 9: Mouse Intestine Tissue Lysate at 50ugPredicted bind size: 72KDObserved bind size: 72KD )
Rabbit anti-Mouse, Rat Growth hormone receptor Polyclonal Antibody | anti-GHR antibody
Anti-Growth hormone receptor antibody
Western Blot (WB)
(Anti-GHR antibody, MBS175741, Western blottingAll lanes: Anti GHR (MBS175741) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Kidney Tissue Lysate at 50ugLane 3: Rat Spleen Tissue Lysate at 50ugLane 4: Rat Intestine Tissue Lysate at 50ugLane 5: Mouse Spleen Tissue Lysate at 50ugLane 6: Mouse Testis Tissue Lysate at 50ugLane 7: Mouse Liver Tissue Lysate at 50ugLane 8: Mouse Kidney Tissue Lysate at 50ugLane 9: Mouse Intestine Tissue Lysate at 50ugPredicted bind size: 72KDObserved bind size: 72KD )
Western Blot (WB)
(Anti-GHR antibody, MBS175741, Western blottingAll lanes: Anti GHR (MBS175741) at 0.5ug/mlLane 1: Rat Liver Tissue Lysate at 50ugLane 2: Rat Kidney Tissue Lysate at 50ugLane 3: Rat Spleen Tissue Lysate at 50ugLane 4: Rat Intestine Tissue Lysate at 50ugLane 5: Mouse Spleen Tissue Lysate at 50ugLane 6: Mouse Testis Tissue Lysate at 50ugLane 7: Mouse Liver Tissue Lysate at 50ugLane 8: Mouse Kidney Tissue Lysate at 50ugLane 9: Mouse Intestine Tissue Lysate at 50ugPredicted bind size: 72KDObserved bind size: 72KD )
Background: The GHR locus to human chromosome 5p13.1-p12 and to mouse chromosome 15. Additionally, its gene has 9 exons that encode the receptor and several additional exons in the 5-prime untranslated region. The coding exons span at least 87 kb. GHR consists of an extracellular domain of 246 amino acids, a single transmembrane domain, and a cytoplasmic domain. Exons 3 to 7 encode the extracellular domain. There are 2 isoforms of GHR in humans, generated by retention or exclusion of exon 3 during splicing: a full-length isoform and an isoform that lacks exon 3(d3GHR). Furthermore, the two isoforms of GHR are expressed in the placenta and appeared to be due to alternative splicing. In cirrhosis, there is a state of acquired GH resistance, as defined by high circulating GH levels with low IGF1 levels. Moreover, Mutations in the GHR gene have been demonstrated as the cause of Laron syndrome, also known as the growth hormone insensitivity syndrome(GHIS).
NCBI and Uniprot Product Information
Uniprot Description
GH receptor: Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway. Defects in GHR are a cause of Laron syndrome (LARS). A severe form of growth hormone insensitivity characterized by growth impairment, short stature, dysfunctional growth hormone receptor, and failure to generate insulin-like growth factor I in response to growth hormone. Defects in GHR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the type I cytokine receptor family. Type 1 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, cytokine; Membrane protein, integral
Cellular Component: extracellular space; extrinsic to membrane; cell surface; mitochondrion; cell soma; membrane; integral to plasma membrane; cytoplasm; integral to membrane; plasma membrane; extracellular region; nucleus; receptor complex
Molecular Function: growth hormone receptor activity; hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; peptide hormone binding; growth factor binding; SH2 domain binding; protein phosphatase binding; protein kinase binding
Biological Process: activation of JAK protein; succinate metabolic process; oxaloacetate metabolic process; hormone-mediated signaling; activation of MAPK activity; positive regulation of JAK-STAT cascade; positive regulation of multicellular organism growth; tyrosine phosphorylation of JAK2 protein; fatty acid metabolic process; response to estradiol stimulus; 2-oxoglutarate metabolic process; allantoin metabolic process; creatinine metabolic process; isoleucine metabolic process; cytokine and chemokine mediated signaling pathway; valine metabolic process; citrate metabolic process; regulation of multicellular organism growth; endocytosis; JAK-STAT cascade; creatine metabolic process; multicellular organismal metabolic process; cellular response to hormone stimulus; positive regulation of peptidyl-tyrosine phosphorylation; insulin-like growth factor receptor signaling pathway; taurine metabolic process
Research Articles on GHR
Similar Products
Product Notes
The GHR ghr (Catalog #AAA175741) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-Growth hormone receptor antibody reacts with Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Growth hormone receptor can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the GHR ghr for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Growth hormone receptor, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
If you are ready to order, navigate to Shopping Cart and get ready to checkout.
