Western Blot (WB)
(Western Blot: Sample: Human Liver Tissue.)
Rabbit anti-Human Growth Arrest Specific Protein 6 (GAS6) Polyclonal Antibody | anti-GAS6 antibody
Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6)
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
Western Blot (WB)
(Western Blot: Sample: Human Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Human Liver Tissue.)
Western Blot (WB)
(Western Blot: Sample: Recombinant GAS6, Human.)
Western Blot (WB)
(Western Blot: Sample: Recombinant GAS6, Human.)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Thyroid Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Thyroid Cancer Tissue)
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Thyroid cancer Tissue))
Immunohistochemistry (IHC)
(DAB staining on IHC-P; Samples: Human Thyroid cancer Tissue))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
Uniprot Description
GAS6: Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Ligand, receptor tyrosine kinase; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 13q34
Cellular Component: cytoplasm; endoplasmic reticulum lumen; extracellular region; extracellular space; Golgi lumen
Molecular Function: calcium ion binding; caspase inhibitor activity; molecular adaptor activity; phosphatidylserine binding; protein binding; protein tyrosine kinase activator activity; receptor binding; receptor ligand activity; receptor tyrosine kinase binding; voltage-gated calcium channel activity
Biological Process: activation of protein kinase B activity; apoptosis; apoptotic cell clearance; cell adhesion; cell cycle arrest; cell migration; cell proliferation; cell-substrate adhesion; cellular protein metabolic process; cellular response to starvation; entry of virus into host cell; enzyme linked receptor protein signaling pathway; ER to Golgi vesicle-mediated transport; fusion of virus membrane with host plasma membrane; leukocyte migration; negative regulation of apoptosis; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of interferon-gamma production; negative regulation of interleukin-1 secretion; negative regulation of interleukin-6 production; negative regulation of protein import into nucleus, translocation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; negative regulation of tumor necrosis factor production; neuron migration; organ regeneration; peptidyl-serine phosphorylation; phagocytosis; platelet activation; platelet degranulation; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of fibroblast proliferation; positive regulation of glomerular filtration; positive regulation of natural killer cell differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phagocytosis; positive regulation of protein export from nucleus; positive regulation of protein kinase activity; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; positive regulation of TOR signaling pathway; post-translational protein modification; protein amino acid phosphorylation; protein kinase B signaling; receptor-mediated virion attachment to host cell; regulation of growth; signal peptide processing; signal transduction; viral genome replication
Research Articles on GAS6
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Product Notes
The GAS6 gas6 (Catalog #AAA2005929) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Polyclonal Antibody to Growth Arrest Specific Protein 6 (GAS6) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Growth Arrest Specific Protein 6 (GAS6) can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB). Western blotting: 1:100-400 Immunocytochemistry in formalin fixed cells: 1:100-500 Immunohistochemistry in formalin fixed frozen section: 1:100-500 Immunohistochemistry in paraffin section: 1:50-200 Enzyme-linked Immunosorbent Assay: 1:100-200. Researchers should empirically determine the suitability of the GAS6 gas6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Growth Arrest Specific Protein 6 (GAS6), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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