Rabbit anti-Human GRM7 Polyclonal Antibody | anti-GRM7 antibody

GRM7, NT (GRM7, GPRC1G, MGLUR7, Metabotropic glutamate receptor 7) (Biotin)

Cat. Num. AAA6304516

• Gene Names: GRM7; GLUR7; MGLU7; GPRC1G; MGLUR7
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GRM7; Polyclonal Antibody; NT (GRM7; GPRC1G; MGLUR7; Metabotropic glutamate receptor 7) (Biotin); Metabotropic glutamate receptor 7; anti-GRM7 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.

• Applicable Applications for anti-GRM7 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:100-500; ELISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: GRM7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 239-269 amino acids from the N-terminal region of human GRM7.
• Conjugate: Biotin
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(GRM7 Antibody (N-term) western blot analysis in 293 cell line lysates (35ug/lane).This demonstrates the GRM7 antibody detected the GRM7 protein (arrow).)

Related Product Information for anti-GRM7 antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-GRM7 antibody

Antibodies; G Protein Receptors

References

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Saus, E., et al. J Psychiatr Res 44(14):971-978(2010). Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010): Joslyn, G., et al. Alcohol. Clin. Exp. Res. 34(5):800-812(2010). Schulz, H.L., et al. Neurosci. Lett. 326(1):37-40(2002).

NCBI and Uniprot Product Information

• NCBI GI #: 4504147
• NCBI GeneID: 2917
• NCBI Accession #: NP_000835.1; NP_870989.1
• NCBI GenBank Nucleotide #: NM_000844.3
• UniProt Accession #: Q14831; Q8NFS2; Q8NFS3; Q8NFS4
• Molecular Weight: 102,251 Da
• NCBI Official Full Name: metabotropic glutamate receptor 7 isoform a
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 7
• NCBI Official Symbol: GRM7
• NCBI Official Synonym Symbols: GLUR7; MGLU7; GPRC1G; MGLUR7
• NCBI Protein Information: metabotropic glutamate receptor 7
• UniProt Protein Name: Metabotropic glutamate receptor 7
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM7
• UniProt Synonym Gene Names: GPRC1G; MGLUR7; mGluR7
• UniProt Entry Name: GRM7_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]

Uniprot Description

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: presynaptic membrane; asymmetric synapse; postsynaptic membrane; axon; integral to plasma membrane; dendrite; presynaptic active zone; integral to membrane; plasma membrane; dendritic shaft; cell cortex; receptor complex

Molecular Function: voltage-gated calcium channel activity; group III metabotropic glutamate receptor activity; glutamate binding; calcium channel regulator activity; calcium ion binding; glutamate receptor activity; PDZ domain binding

Biological Process: behavioral fear response; regulation of synaptic transmission, glutamatergic; negative regulation of glutamate secretion; short-term memory; sensory perception of smell; negative regulation of adenylate cyclase activity; regulation of cyclase activity; transmission of nerve impulse; synaptic transmission; negative regulation of cAMP biosynthetic process; sensory perception of sound; adult behavior; conditioned taste aversion; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway