Goat anti-Human mGluR7 Polyclonal Antibody | anti-GRM7 antibody

mGluR7 (G Protein-coupled Metabotropic Glutamate Receptor, GRM7, FLJ40498, GLUR7, GPRC1G, mGlu7)

Cat. Num. AAA622356

• Gene Names: GRM7; GLUR7; MGLU7; GPRC1G; MGLUR7; FLJ40498
• Reactivity: Human
• Applications: ELISA, Western Blot
• Purity: Affinity Purified; Purified by antigen immunoaffinity chromatography.
• Synonyms: mGluR7; Polyclonal Antibody; mGluR7 (G Protein-coupled Metabotropic Glutamate Receptor; GRM7; FLJ40498; GLUR7; GPRC1G; mGlu7); Anti -mGluR7 (G Protein-coupled Metabotropic Glutamate Receptor; anti-GRM7 antibody

• Host: Goat
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes both reported isoforms of human GRM7 at ~100kD. Species sequence homology: mouse and rat.
• Purity/Purification: Affinity Purified; Purified by antigen immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in Tris saline, 0.02% sodium azide, pH 7.2, 0.5% BSA.

• Applicable Applications for anti-GRM7 antibody: ELISA (EL/EIA), Western Blot (WB)
• Application Notes: Suitable for use in ELISA and Western Blot.; Dilution: ELISA: 1:32000; Western Blot: 0.5-2ug/ml
• Immunogen: Synthetic peptide corresponding to NCKLTISGSKKEDT, from the internal region of human GRM7 (NP_000835.1; NP_870989.1).
• Positive Control: Human, Mouse, and Rat Brain lysates
• Preparation and Storage: May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Chemiluminescence

(MBS622356 (0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.)

Related Product Information for anti-GRM7 antibody

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. Metabotropic glutamate receptor 7 (mGLUR7), also called GRM7 (G protein-coupled

Product Categories/Family for anti-GRM7 antibody

Antibodies; Abs to G Protein Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 32528268
• NCBI GeneID: 2917
• NCBI Accession #: NP_870989.1
• NCBI GenBank Nucleotide #: NM_181874.2
• UniProt Accession #: Q14831; Q8NFS2; Q8NFS3; Q8NFS4; Q59G95
• Molecular Weight: 102,251 Da
• NCBI Official Full Name: metabotropic glutamate receptor 7 isoform b
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 7
• NCBI Official Symbol: GRM7
• NCBI Official Synonym Symbols: GLUR7; MGLU7; GPRC1G; MGLUR7; FLJ40498
• NCBI Protein Information: metabotropic glutamate receptor 7; OTTHUMP00000155219; OTTHUMP00000206960; OTTHUMP00000206961; OTTHUMP00000214674; OTTHUMP00000214675; OTTHUMP00000238688
• UniProt Protein Name: Metabotropic glutamate receptor 7
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM7
• UniProt Synonym Gene Names: GPRC1G; MGLUR7
• UniProt Entry Name: GRM7_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Uniprot Description

mGluR7: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. Belongs to the G-protein coupled receptor 3 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 3; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p26.1-p25.1

Cellular Component: presynaptic membrane; asymmetric synapse; postsynaptic membrane; axon; integral to plasma membrane; dendrite; plasma membrane; presynaptic active zone; integral to membrane; cell cortex; dendritic shaft; receptor complex

Molecular Function: voltage-gated calcium channel activity; group III metabotropic glutamate receptor activity; glutamate binding; calcium channel regulator activity; calcium ion binding; glutamate receptor activity; PDZ domain binding

Biological Process: behavioral fear response; regulation of synaptic transmission, glutamatergic; negative regulation of glutamate secretion; short-term memory; negative regulation of adenylate cyclase activity; sensory perception of smell; regulation of cyclase activity; transmission of nerve impulse; synaptic transmission; negative regulation of cAMP biosynthetic process; sensory perception of sound; conditioned taste aversion; adult behavior; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway