Rabbit anti-Human GRM2 Polyclonal Antibody | anti-GRM2 antibody

GRM2 antibody

Cat. Num. AAA535487

• Gene Names: GRM2; GLUR2; mGlu2; GPRC1B; MGLUR2
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: GRM2 antibody was purified by affinity chromatography.
• Synonyms: GRM2; Polyclonal Antibody; GRM2 antibody; Polyclonal GRM2; Anti-GRM2; GRM -2; metabotropic 2; mglur2; Glutamate receptor; GRM 2; metabotropic glutamate receptor type ii; metabotropic glutamate receptor 2; mGlu2 receptor; metabotropic glutamate type 2 receptor; grm2; anti-GRM2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human
• Purity/Purification: GRM2 antibody was purified by affinity chromatography.
• Form/Format: Purified by Immunoaffinity Chromatography and supplied in PBS with 0.1% NaN3.
• Concentration: 1.0 mg/ml (varies by lot)
• Sequence Length: 872

• Applicable Applications for anti-GRM2 antibody: Immunohistochemistry (IHC) Paraffin
• Application Notes: IHC-P: 4 ug/ml
• Biological Significance: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. The receptors in group II, including mGluRs 2 and 3, and group III, including mGluRs 4, 6, 7, and 8, (with some exceptions) prevent the formation of cyclic adenosine monophosphate, or cAMP, by activating a G protein that inhibits the enzyme adenylyl cyclase, which forms cAMP from ATP.
• Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.
• Immunogen: GRM2 antibody was raised in rabbit using a synthetic peptide conjugated to KLH as the immunogen.
• Preparation and Storage: Store at 4 degree C for short term storage. Aliquot and store at -70 degree C for long term storage. Avoid repeated freeze/thaw cycles.

Related Product Information for anti-GRM2 antibody

Rabbit polyclonal GRM2 antibody

Product Categories/Family for anti-GRM2 antibody

Neuroscience

NCBI and Uniprot Product Information

• NCBI GI #: 66529100
• NCBI GeneID: 2912
• NCBI Accession #: NP_000830.2
• NCBI GenBank Nucleotide #: NM_000839.3
• UniProt Accession #: Q14416; Q14CU5; Q52MC6; Q9H3N6; B0M0K7
• Molecular Weight: 95,568 Da
• NCBI Official Full Name: metabotropic glutamate receptor 2 isoform a
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 2
• NCBI Official Symbol: GRM2
• NCBI Official Synonym Symbols: GLUR2; mGlu2; GPRC1B; MGLUR2
• NCBI Protein Information: metabotropic glutamate receptor 2
• UniProt Protein Name: Metabotropic glutamate receptor 2
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: GRM2
• UniProt Synonym Gene Names: GPRC1B; MGLUR2; mGluR2
• UniProt Entry Name: GRM2_HUMAN

NCBI Description

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

mGluR2: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. Belongs to the G-protein coupled receptor 3 family.

Protein type: Membrane protein, integral; GPCR, family 3; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.2

Cellular Component: presynaptic membrane; integral to plasma membrane; axon; dendrite; plasma membrane; intracellular; cell junction

Molecular Function: G-protein coupled receptor activity; group II metabotropic glutamate receptor activity; calcium channel regulator activity; glutamate receptor activity

Biological Process: synaptic transmission; regulation of synaptic transmission, glutamatergic; glutamate secretion; negative regulation of adenylate cyclase activity; metabotropic glutamate receptor, adenylate cyclase inhibiting pathway