Rabbit anti-Human GRM1 Polyclonal Antibody | anti-Grm1 antibody

GRM1, CT (Metabotropic Glutamate Receptor 1, mGluR1, GPRC1A, MGLUR1)

Cat. Num. AAA642970

• Gene Names: Grm1; rcw; wobl; Gprc1a; mGluR1; nmf373; Gm10828; 4930455H15Rik; ENSMUSG00000075319
• Reactivity: Human
• Applications: Western Blot, Immunoprecipitation, Immunohistochemistry
• Purity: Affinity Purified; Purified by immunoaffinity chromatography.
• Synonyms: GRM1; Polyclonal Antibody; CT (Metabotropic Glutamate Receptor 1; mGluR1; GPRC1A; MGLUR1); Anti -GRM1; anti-Grm1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Recognizes human GRM1. Species sequence homology: Mouse and rat.
• Purity/Purification: Affinity Purified; Purified by immunoaffinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.4, 0.2% BSA, 0.05% sodium azide.

• Applicable Applications for anti-Grm1 antibody: Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)
• Application Notes: Suitable for use in Western Blot, Immunoprecipitation and Immunohistochemistry.; Dilution: Immunohistochemistry (Formalin fixed paraffin embedded): 20ug/ml
• Immunogen: Synthetic peptide corresponding to human GRM1 at C-terminal (KLH).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Human Brain, Cerebellum (formalin-fixed, paraffin-embedded) stained with GRM1 antibody at 20ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody alkaline phosphatase-streptavidin and chromogen.)

Related Product Information for anti-Grm1 antibody

The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain.

Product Categories/Family for anti-Grm1 antibody

Antibodies; Abs to G Protein Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 50927519
• NCBI GeneID: 14816
• UniProt Accession #: P97772; Q6AXG4; Q9EPV6
• Molecular Weight: 133,212 Da
• NCBI Official Full Name: Grm1 protein
• NCBI Official Synonym Full Names: glutamate receptor, metabotropic 1
• NCBI Official Symbol: Grm1
• NCBI Official Synonym Symbols: rcw; wobl; Gprc1a; mGluR1; nmf373; Gm10828; 4930455H15Rik; ENSMUSG00000075319
• NCBI Protein Information: metabotropic glutamate receptor 1; G protein coupled receptor, family C, group 1, member A; G protein-coupled receptor, family C, group 1, member A
• UniProt Protein Name: Metabotropic glutamate receptor 1
• Protein Family: Metabotropic glutamate receptor
• UniProt Gene Name: Grm1
• UniProt Synonym Gene Names: Gprc1a; Mglur1; mGluR1
• UniProt Entry Name: GRM1_MOUSE

Uniprot Description

mGluR1: Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system. May participate in the central action of glutamate in the CNS, such as long-term potentiation in the hippocampus and long-term depression in the cerebellum. Homodimer; disulfide-linked. The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP. Belongs to the G-protein coupled receptor 3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 3; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Cellular Component: neuron projection; integral to plasma membrane; postsynaptic density; dendrite; dendritic spine; integral to membrane; cytosol; presynaptic membrane; postsynaptic membrane; membrane; cell soma; axon; plasma membrane; intracellular; nucleus

Molecular Function: G-protein coupled receptor activity; identical protein binding; protein binding; signal transducer activity; PLC activating metabotropic glutamate receptor activity; estrogen receptor binding; glutamate receptor activity

Biological Process: elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of synaptic transmission, glutamatergic; activation of MAPKK activity; activation of MAPK activity; calcium-mediated signaling; locomotory behavior; sensory perception of pain; signal transduction; G-protein coupled receptor protein signaling pathway; regulation of MAPKKK cascade; metabotropic glutamate receptor, phospholipase C activating pathway; protein kinase C activation; metabotropic glutamate receptor signaling pathway; regulation of sensory perception of pain