Rabbit anti-Mouse GRIN2C Polyclonal Antibody | anti-GRIN2C antibody

GRIN2C Antibody (Center)

Cat. Num. AAA9205341

• Gene Names: GRIN2C; NR2C; GluN2C; NMDAR2C
• Reactivity: Mouse
• Applications: Western Blot, ELISA
• Purity: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Synonyms: GRIN2C; Polyclonal Antibody; GRIN2C Antibody (Center); Glutamate receptor ionotropic; NMDA 2C; GluN2C; Glutamate [NMDA] receptor subunit epsilon-3; N-methyl D-aspartate receptor subtype 2C; NMDAR2C; NR2C; anti-GRIN2C antibody

• Host: Rabbit
• Reactivity: Mouse
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Specificity: This GRIN2C antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 567-595 amino acids from the Central region of human GRIN2C.
• Purity/Purification: Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
• Form/Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
• Sequence Positions: 567-595
• Sequence Length: 1233

• Applicable Applications for anti-GRIN2C antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB~~1:1000
• Antigen Type: Synthetic Peptide
• Function: Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+) (PubMed:26875626). Sensitivity to glutamate and channel kinetics depend on the subunit composition (Probable). Plays a role in regulating the balance between excitatory and inhibitory activity of pyramidal neurons in the prefrontal cortex. Contributes to the slow phase of excitatory postsynaptic current, long-term synaptic potentiation, and learning (By similarity).
• Cellular Location: Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein
• Tissue Location: Mainly expressed in brain with predominant expression is in the cerebellum, also present in the hippocampus, amygdala, caudate nucleus, corpus callosum, subthalamic nuclei and thalamus. Detected in the heart, skeletal muscle and pancreas
• Preparation and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Western Blot (WB)

(GRIN2C Antibody (Center) western blot analysis in mouse cerebellum tissue lysates (35ug/lane).This demonstrates the GRIN2C antibody detected the GRIN2C protein (arrow).)

Related Product Information for anti-GRIN2C antibody

N-methyl-D-aspartate (NMDA) receptors are a class of
ionotropic glutamate receptors. NMDA channel has been shown to be
involved in long-term potentiation, an activity-dependent increase
in the efficiency of synaptic transmission thought to underlie
certain kinds of memory and learning. NMDA receptor channels are
heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and
1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B
(GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by
RefSeq].

Product Categories/Family for anti-GRIN2C antibody

Neuroscience; Amyotrophic Lateral Sclerosis (ALS); Phospho Antibodies

References

Need, A.C., et al. Eur. J. Hum. Genet. 17(7):946-957(2009)
Tabakoff, B., et al. BMC Biol. 7, 70 (2009) :
Shi, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (7), 1270-1277 (2008) :
Self, R.L., et al. Brain Res. 995(1):39-45(2004)
Krapivinsky, G., et al. Neuron 40(4):775-784(2003)

NCBI and Uniprot Product Information

• NCBI GI #: 55770854
• NCBI GeneID: 2905
• NCBI Accession #: NP_000826.2
• NCBI GenBank Nucleotide #: NM_000835.4
• UniProt Accession #: Q14957; B2RTT1
• Molecular Weight: 134209
• NCBI Official Full Name: glutamate receptor ionotropic, NMDA 2C isoform 1
• NCBI Official Synonym Full Names: glutamate receptor, ionotropic, N-methyl D-aspartate 2C
• NCBI Official Symbol: GRIN2C
• NCBI Official Synonym Symbols: NR2C; GluN2C; NMDAR2C
• NCBI Protein Information: glutamate receptor ionotropic, NMDA 2C
• UniProt Protein Name: Glutamate receptor ionotropic, NMDA 2C
• Protein Family: Glutamate receptor ionotropic
• UniProt Gene Name: GRIN2C
• UniProt Synonym Gene Names: NMDAR2C; GluN2C; NMDAR2C; NR2C
• UniProt Entry Name: NMDE3_HUMAN

NCBI Description

This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of ionotropic glutamate receptor. NMDA receptors are found in the central nervous system, are permeable to cations and have an important role in physiological processes such as learning, memory, and synaptic development. The receptor is a tetramer of different subunits (typically heterodimer of subunit 1 with one or more of subunits 2A-D), forming a channel that is permeable to calcium, potassium, and sodium, and whose properties are determined by subunit composition. Alterations in the subunit composition of the receptor are associated with pathophysiological conditions such as Parkinson's disease, Alzheimer's disease, depression, and schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]

Uniprot Description

NMDAR2C: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2C/GRIN2C subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, calcium; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 17q25.1

Cellular Component: postsynaptic membrane; integral to plasma membrane; postsynaptic density; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; N-methyl-D-aspartate selective glutamate receptor activity; protein N-terminus binding; cation channel activity; PDZ domain binding

Biological Process: synaptic transmission; synaptic transmission, glutamatergic; protein localization; transport; glutamate signaling pathway; directional locomotion; ionotropic glutamate receptor signaling pathway; response to wounding; regulation of excitatory postsynaptic membrane potential; neuromuscular process controlling balance; negative regulation of protein catabolic process