Western Blot (WB)
(GRIN2A Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the GRIN2A antibody detected the GRIN2A protein (arrow).)
Rabbit anti-Mouse GRIN2A Polyclonal Antibody | anti-GRIN2A antibody
GRIN2A Antibody (Center)
Western Blot (WB)
(GRIN2A Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the GRIN2A antibody detected the GRIN2A protein (arrow).)
Western Blot (WB)
(GRIN2A Antibody (Center) western blot analysis in mouse heart tissue lysates (35ug/lane).This demonstrates the GRIN2A antibody detected the GRIN2A protein (arrow).)
Immunohistochemistry (IHC)
(GRIN2A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GRIN2A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(GRIN2A Antibody (Center) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of GRIN2A Antibody (Center) for immunohistochemistry. Clinical relevance has not been evaluated.)
ionotropic glutamate-gated ion channels. These receptors have been
shown to be involved in long-term potentiation, an
activity-dependent increase in the efficiency of synaptic
transmission thought to underlie certain kinds of memory and
learning. NMDA receptor channels are heteromers composed of the key
receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2
subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and
NMDAR2D (GRIN2D). Alternatively spliced transcript variants
encoding different isoforms have been found for this gene.
Shimada, M., et al. Hum. Genet. 128(4):433-441(2010)
Saus, E., et al. J Psychiatr Res 44(14):971-978(2010)
Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) :
King, J.E., et al. Am. J. Pathol. 176(6):2819-2830(2010)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the glutamate-gated ion channel protein family. The encoded protein is an N-methyl-D-aspartate (NMDA) receptor subunit. NMDA receptors are both ligand-gated and voltage-dependent, and are involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. These receptors are permeable to calcium ions, and activation results in a calcium influx into post-synaptic cells, which results in the activation of several signaling cascades. Disruption of this gene is associated with focal epilepsy and speech disorder with or without mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Uniprot Description
NMDAR2A: a subunit of N-methyl-D-aspartate (NMDA) receptors, members of the glutamate receptor channel superfamily. Possesses high calcium permeability and voltage-dependent sensitivity to magnesium and is modulated by glycine. Plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. Mediates neuronal functions in glutamate neurotransmission.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 16p13.2
Cellular Component: presynaptic membrane; postsynaptic membrane; synaptic vesicle; cell surface; integral to plasma membrane; endoplasmic reticulum; dendrite; plasma membrane; cell junction; N-methyl-D-aspartate selective glutamate receptor complex
Molecular Function: protein binding; extracellular-glutamate-gated ion channel activity; zinc ion binding; N-methyl-D-aspartate selective glutamate receptor activity; calcium channel activity
Biological Process: response to drug; synaptic transmission, glutamatergic; startle response; glutamate signaling pathway; positive regulation of apoptosis; response to amphetamine; regulation of synaptic plasticity; sleep; sensory perception of pain; dopamine metabolic process; memory; synaptic transmission; protein localization; learning and/or memory; response to ethanol; neurogenesis; ionotropic glutamate receptor signaling pathway; directional locomotion; transport; response to wounding; visual learning; regulation of sensory perception of pain; negative regulation of protein catabolic process; regulation of excitatory postsynaptic membrane potential; serotonin metabolic process
Disease: Epilepsy, Focal, With Speech Disorder And With Or Without Mental Retardation
Research Articles on GRIN2A
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Product Notes
The GRIN2A grin2a (Catalog #AAA9209581) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1057-1084. The GRIN2A Antibody (Center) reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's GRIN2A can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the GRIN2A grin2a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRIN2A, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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