Goat GRIK5/KA2 Polyclonal Antibody | anti-GRIK5 antibody
Goat anti-GRIK5/KA2 Antibody
Western Blot: Preliminary experiments gave an approx.26kDa band in Human Brain (Frontal Cortex and Hippocampus) lysates after 1ug/ml antibody staining. Please note that currently we can not find an explanation in the literature for the band we observe given the calculated size of 109kDa according to NP_002079.3. The 26kDa band was successfully blocked by incubation with the immunizing peptide.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein that belongs to the glutamate-gated ionic channel family. Glutamate functions as the major excitatory neurotransmitter in the central nervous system through activation of ligand-gated ion channels and G protein-coupled membrane receptors. The protein encoded by this gene forms functional heteromeric kainate-preferring ionic channels with the subunits encoded by related gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Uniprot Description
GluR KA2: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. GRIK5 subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component: cell junction; dendrite; endoplasmic reticulum; kainate selective glutamate receptor complex; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic membrane; terminal button
Molecular Function: extracellular-glutamate-gated ion channel activity; identical protein binding; kainate selective glutamate receptor activity; ligand-gated ion channel activity; PDZ domain binding; SH3 domain binding
Biological Process: establishment of cellular localization; ionotropic glutamate receptor signaling pathway; positive regulation of neuron apoptosis; protein retention in ER; receptor clustering; regulation of excitatory postsynaptic membrane potential; regulation of synaptic vesicle fusion to presynaptic membrane; synaptic transmission, glutamatergic
Research Articles on GRIK5
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Product Notes
The GRIK5 grik5 (Catalog #AAA422148) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat anti-GRIK5/KA2 Antibody reacts with Expected from sequence similarity: Human, Rat, Cow and may cross-react with other species as described in the data sheet. AAA Biotech's GRIK5/KA2 can be used in a range of immunoassay formats including, but not limited to, Peptide ELISA (EIA). Peptide ELISA: Antibody detection limit dilution 1: 32000. Western Blot: Preliminary experiments gave an approx.26kDa band in Human Brain (Frontal Cortex and Hippocampus) lysates after 1ug/ml antibody staining. Please note that currently we can not find an explanation in the literature for the band we observe given the calculated size of 109kDa according to NP_002079.3. The 26kDa band was successfully blocked by incubation with the immunizing peptide. Researchers should empirically determine the suitability of the GRIK5 grik5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: GPAGPRELAE HE. It is sometimes possible for the material contained within the vial of "GRIK5/KA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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