Rabbit GRHL1 Polyclonal Antibody | anti-GRHL1 antibody
GRHL1 Antibody
Gene Names
GRHL1; MGR; NH32; LBP32; TFCP2L2
Reactivity
Human, Mouse, Rat
Applications
ELISA
Purity
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Synonyms
GRHL1; Polyclonal Antibody; GRHL1 Antibody; Grainyhead-like protein 1 homolog; grhl1; GRHL1_HUMAN; LBP32; Mammalian grainyhead; MGR; NH32; TFCP2L2; Transcription factor CP2-like 2; Transcription factor LBP-32; anti-GRHL1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
Rabbit IgG
Specificity
GRHL1 Antibody detects endogenous levels of GRHL1.
Purity/Purification
The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin (Thermo Fisher Scientific).
Form/Format
Liquid. Rabbit IgG in phosphate buffered saline, pH7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-GRHL1 antibody
ELISA (EIA)(peptide)
Application Notes
ELISA(peptide): 1:20000-1:40000
Immunogen
A synthesized peptide derived from human GRHL1.
Conjugation
Unconjugated
Similarity
Belongs to the grh/CP2 family. Grainyhead subfamily.
Subunit Structure
Binds DNA as homodimer. Homodimer, also forms heterodimers with GRHL2 or GRHL3.
Tissue Specificity
Isoform 1 is highly expressed in brain, pancreas, tonsil, placenta and kidney. Isoform 2 is highly expressed in brain and liver. Expressed at very low levels in non-steroidogenic cells.
Function
Transcription factor involved in epithelial development. Binds directly to the consensus DNA sequence 5'-AACCGGTT-3'. Important regulator of DSG1 in the context of hair anchorage and epidermal differentiation, participates in the maintenance of the skin barrier. There is no genetic interaction with GRHL3, no functional cooperativity due to diverse target gene selectivity during epithelia development (By similarity).Functions as transcription activator.May function as a repressor in tissues where both isoform 1 and isoform 2 are expressed.
Preparation and Storage
Store at -20 degree C. Stable for 12 months from date of receipt.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
70,113 Da
NCBI Official Full Name
grainyhead-like protein 1 homolog
NCBI Official Synonym Full Names
grainyhead-like 1 (Drosophila)
NCBI Official Symbol
GRHL1
NCBI Official Synonym Symbols
MGR; NH32; LBP32; TFCP2L2
NCBI Protein Information
grainyhead-like protein 1 homolog; LBP protein 32; mammalian grainyhead; transcription factor LBP-32; transcription factor CP2-like 2
UniProt Protein Name
Grainyhead-like protein 1 homolog
Protein Family
UniProt Gene Name
GRHL1
UniProt Synonym Gene Names
LBP32; MGR; TFCP2L2
UniProt Entry Name
GRHL1_HUMAN
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Product Notes
The GRHL1 grhl1 (Catalog #AAA9631057) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GRHL1 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GRHL1 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA)(peptide). ELISA(peptide): 1:20000-1:40000. Researchers should empirically determine the suitability of the GRHL1 grhl1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GRHL1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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