Rabbit anti-Human Grb2-associated binder 1 Polyclonal Antibody | anti-GAB1 antibody

Grb2-associated binder 1 Polyclonal Antibody

Cat. Num. AAA668047

• Reactivity: Human
• Applications: Western Blot
• Synonyms: Grb2-associated binder 1; Polyclonal Antibody; Grb2-associated binder 1 Polyclonal Antibody; anti-GAB1 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Form/Format: Purified (Liquid)
• Concentration: 0.5mg/ml, 200µl (varies by lot)
• Sequence Length: 694

• Applicable Applications for anti-GAB1 antibody: Western Blot (WB)
• Application Notes: Western Blot: 2-4 µg/ml
• Antigen: Grb2-associated binder 1
• Immunogen: A partial recombinant Grb2-associated binder 1 protein (amino acids 110-320) was used as the immunogen for this antibody.
• Preparation and Storage: Store antibody at 4 degree C, stable for 6 months. For long-term storage, store at -20 degree C. Avoid repeated freeze and thaw cycles. Expire 1 year from date of purchase.

Western Blot (WB)

(Expression analysis of Grb2-associated binder 1. Anti-Grb2-associated binder 1 antibody (11-8085) was used at 4 µg/ml on (1) A431 and (2) K562 lysates.)

Product Categories/Family for anti-GAB1 antibody

Cell signalling

NCBI and Uniprot Product Information

• NCBI GI #: 46370073
• NCBI GeneID: 2549
• NCBI Accession #: NP_002030.2
• NCBI GenBank Nucleotide #: NM_002039.3
• UniProt Accession #: Q13480; Q4W5G2; Q6P1W2; A8K152
• Molecular Weight: 80,005 Da
• NCBI Official Full Name: GRB2-associated-binding protein 1 isoform b
• NCBI Official Synonym Full Names: GRB2-associated binding protein 1
• NCBI Official Symbol: GAB1
• NCBI Protein Information: GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1
• UniProt Protein Name: GRB2-associated-binding protein 1
• Protein Family: GPI transamidase component
• UniProt Gene Name: GAB1
• UniProt Entry Name: GAB1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Description

GAB1: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: cytosol

Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity

Biological Process: epidermal growth factor receptor signaling pathway; cell proliferation; epidermis development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; heart development; insulin receptor signaling pathway; innate immune response; platelet-derived growth factor receptor signaling pathway; response to oxidative stress; regulation of cell migration; activation of JNK activity