Rabbit GAB1 Polyclonal Antibody | anti-GAB1 antibody

GAB1 Polyclonal Antibody

Cat. Num. AAA2524757

• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Immunohistochemistry
• Purity: Antigen affinity purification
• Synonyms: GAB1; Polyclonal Antibody; GAB1 Polyclonal Antibody; anti-GAB1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.7mg/mL (varies by lot)
• Sequence Length: 694

• Applicable Applications for anti-GAB1 antibody: ELISA (EIA), Immunohistochemistry (IHC)
• Application Notes: IHC: 1:25-1:100
• Immunogen: Recombinant protein of human GAB1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using GAB1 Polyclonal Antibody at dilution 1:40)

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded Human brain tissue using GAB1 Polyclonal Antibody at dilution 1:40)

Related Product Information for anti-GAB1 antibody

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Product Categories/Family for anti-GAB1 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 46370073
• NCBI GeneID: 2549
• NCBI Accession #: NP_002030.2
• NCBI GenBank Nucleotide #: NM_002039.3
• Molecular Weight: 80,005 Da
• NCBI Official Full Name: GRB2-associated-binding protein 1 isoform b
• NCBI Official Synonym Full Names: GRB2-associated binding protein 1
• NCBI Official Symbol: GAB1
• NCBI Protein Information: GRB2-associated-binding protein 1; GRB2-associated binder 1; growth factor receptor bound protein 2-associated protein 1
• UniProt Protein Name: GRB2-associated-binding protein 1
• Protein Family: GPI transamidase component
• UniProt Gene Name: GAB1
• UniProt Entry Name: GAB1_HUMAN

NCBI Description

The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Description

GAB1: Adapter protein that plays a role in intracellular signaling cascades triggered by activated receptor-type kinases. Plays a role in FGFR1 signaling. Probably involved in signaling by the epidermal growth factor receptor (EGFR) and the insulin receptor (INSR). Interacts with GRB2 and with other SH2-containing proteins. Interacts with phosphorylated LAT2. Interacts with PTPRJ. Identified in a complex containing FRS2, GRB2, GAB1, PIK3R1 and SOS1. Interacts (phosphorylated) with PTPN11. Interacts with HCK. Belongs to the GAB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: cytosol

Molecular Function: protein binding; signal transducer activity; SH3/SH2 adaptor activity

Biological Process: epidermal growth factor receptor signaling pathway; cell proliferation; epidermis development; fibroblast growth factor receptor signaling pathway; phosphoinositide-mediated signaling; nerve growth factor receptor signaling pathway; heart development; insulin receptor signaling pathway; innate immune response; platelet-derived growth factor receptor signaling pathway; response to oxidative stress; regulation of cell migration; activation of JNK activity