Rabbit GPR78 Polyclonal Antibody | anti-GPR78 antibody

Rabbit Polyclonal to Human GPR78

Cat. Num. AAA244738

• Reactivity: Chimpanzee, Human; Predicted Reactivity: Gorilla, Orangutan, Gibbon (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPR78; Polyclonal Antibody; Rabbit Polyclonal to Human GPR78; Anti-GPR78 Antibody (Cytoplasmic Domain) IHC-plus; G protein-coupled receptor 78; G-protein coupled receptor 78; Human GPR78; anti-GPR78 antibody

• Host: Rabbit
• Reactivity: Chimpanzee, Human; Predicted Reactivity: Gorilla, Orangutan, Gibbon (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPR78. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 363

• Applicable Applications for anti-GPR78 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (14 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human GPR78. Percent identity with other species by BLAST analysis: Human, Chimpanzee (100%); Gorilla, Orangutan, Gibbon (94%); Monkey (88%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPR78 antibody was raised against synthetic 17 amino acid peptide from 3rd cytoplasmic domain of human GPR78. Percent identity with other species by BLAST analysis: Human, Chimpanzee (100%); Gorilla, Orangutan, Gibbon (94%); Monkey (88%).
• Antigen Modification: Cytoplasmic Domain
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPR78 antibody IHC of human placenta, villi. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR78 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPR78 antibody

G protein-coupled receptor GPR78 is an Orphan-U GPCR with an unknown ligand.

Product Categories/Family for anti-GPR78 antibody

Family: GPCR; Subfamily: Orphan-U

NCBI and Uniprot Product Information

• NCBI GI #: 36951034
• NCBI GeneID: 27201
• NCBI Accession #: NP_543009.2
• NCBI GenBank Nucleotide #: NM_080819.4
• UniProt Accession #: Q96P69; Q8NGV3
• Molecular Weight: 39,332 Da
• NCBI Official Full Name: G-protein coupled receptor 78
• NCBI Official Synonym Full Names: G protein-coupled receptor 78
• NCBI Official Symbol: GPR78
• NCBI Protein Information: G-protein coupled receptor 78
• UniProt Protein Name: G-protein coupled receptor 78
• Protein Family: G-protein coupled receptor
• UniProt Gene Name: GPR78
• UniProt Entry Name: GPR78_HUMAN

NCBI Description

The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. This is an orphan receptor, which displays significant level of constitutive activity. Association analysis shows preliminary evidence for the involvement of this gene in susceptibility to bipolar affective disorder and schizophrenia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011]

Uniprot Description

GPR78: Orphan receptor. Displays a significant level of constitutive activity. Its effect is mediated by G(s)-alpha protein that stimulate adenylate cyclase, resulting in an elevation of intracellular cAMP. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 4p16.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein signaling, adenylate cyclase activating pathway