Rabbit anti-Human, Mouse AGA Polyclonal Antibody | anti-AGA antibody

AGA Antibody

Cat. Num. AAA9414983

• Gene Names: AGA; GA; AGU; ASRG
• Reactivity: Human, Mouse
• Applications: Western Blot, Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: AGA; Polyclonal Antibody; AGA Antibody; GA; AGU; ASRG; anti-AGA antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total AGA protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 0.8 mg/ml (varies by lot)
• Sequence Length: 346

• Applicable Applications for anti-AGA antibody: Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Western blotting: 1:200-1:1000; Immunohistochemistry: 1:15-1:50
• Immunogen Type: Recombinant Protein
• Immunogen Description: Fusion protein corresponding to a region derived from internal residues of human Aspartylglucosaminidase
• Target Name: AGA
• Preparation and Storage: Store at -20 degree C

Testing Data

(Gel: 10%SDS-PAGE Lysates (from left to right): Mouse kidney tissue, human testis and thyroid cancer tissue Amount of lysate: 40ug per lane Primary antibody: 1/100 dilution Secondary antibody dilution: 1/8000 Exposure time: 10 seconds)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue using at dilution 1/20.)

Related Product Information for anti-AGA antibody

Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified.

Product Categories/Family for anti-AGA antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 285002251
• NCBI GeneID: 175
• NCBI Accession #: NP_000018.2
• NCBI GenBank Nucleotide #: NM_000027.3
• UniProt Accession #: P20933; Q4W5Q2; Q6FHN6; Q9UCK6; Q9UCK7; Q9UCK8; B2R7H2; D3DP47
• Molecular Weight: 37,208 Da
• NCBI Official Full Name: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase isoform 1 preproprotein
• NCBI Official Synonym Full Names: aspartylglucosaminidase
• NCBI Official Symbol: AGA
• NCBI Official Synonym Symbols: GA; AGU; ASRG
• NCBI Protein Information: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
• UniProt Protein Name: N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase
• Protein Family: Agaricus bisporus lectin
• UniProt Gene Name: AGA
• UniProt Entry Name: ASPG_HUMAN

NCBI Description

Aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Jan 2010]

Uniprot Description

AGA: a catabolic enzyme, aspartylglucosaminidase is involved in the catabolism of N-linked oligosaccharides of glycoproteins. It cleaves asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins. The lysosomal storage disease aspartylglycosaminuria is caused by a deficiency in the AGA enzyme.

Protein type: Glycan Metabolism - other glycan degradation; Hydrolase; EC 3.5.1.26

Chromosomal Location of Human Ortholog: 4q34.3

Cellular Component: endoplasmic reticulum; lysosome

Molecular Function: peptidase activity; protein self-association; N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity

Biological Process: protein maturation; protein deglycosylation; proteolysis

Disease: Aspartylglucosaminuria