Rabbit GPR64 Polyclonal Antibody | anti-GPR64 antibody

Rabbit Polyclonal to Human GPR64

Cat. Num. AAA242978

• Gene Names: GPR64; HE6; EDDM6; TM7LN2
• Reactivity: Gibbon, Gorilla, Hamster, Human, Monkey, Mouse, Rat; Predicted Reactivity: Bat, Bovine, Dog, Horse, Rabbit (at least 90% immunogen sequence identity)
• Applications: Immunohistochemistry
• Purity: Immunoaffinity Purified
• Synonyms: GPR64; Polyclonal Antibody; Rabbit Polyclonal to Human GPR64; Anti-GPR64 Antibody (C-Terminus) IHC-plus; Epididymal protein 6; G protein-coupled receptor 64; EDDM6; G-protein coupled receptor 64; HE6; TM7LN2; Human GPR64; anti-GPR64 antibody

• Host: Rabbit
• Reactivity: Gibbon, Gorilla, Hamster, Human, Monkey, Mouse, Rat; Predicted Reactivity: Bat, Bovine, Dog, Horse, Rabbit (at least 90% immunogen sequence identity)
• Clonality: Polyclonal
• Specificity: Human GPR64. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.1% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 1014

• Applicable Applications for anti-GPR64 antibody: Immunohistochemistry (IHC - Paraffin)
• Application Notes: IHC-P (5 ug/ml)
• Target Species: Human
• Immunogen Description: Synthetic 20 amino acid peptide from C-terminus of human GPR64. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Opossum (100%); Bovine, Panda, Rabbit (95%).
• Immunogen Type: Synthetic peptide
• Immunogen: GPR64 antibody was raised against synthetic 20 amino acid peptide from C-terminus of human GPR64. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Opossum (100%); Bovine, Panda, Rabbit (95%); Dog, Bat, Horse (90%); Pig, Platypus (80%).
• Antigen Modification: C-Terminus
• Preparation and Storage: Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC)

(Anti-GPR64 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR64 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Immunohistochemistry (IHC)

(Anti-GPR64 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Related Product Information for anti-GPR64 antibody

GPR64 is an Orphan-B GPCR with an unknown ligand. HE6 is endogenously cleaved into two pieces at the GPCR proteolytic site (GPS) located adjacent to the first transmembrane helix as a mechanism to compartmentalize the cell adhesion and GPCR activation functions.

Product Categories/Family for anti-GPR64 antibody

Family: GPCR; Subfamily: Orphan-B

NCBI and Uniprot Product Information

• NCBI GI #: 119943129
• NCBI GeneID: 10149
• NCBI Accession #: NP_005747.2
• NCBI GenBank Nucleotide #: NM_005756.3
• UniProt Accession #: Q8IZP9; O00406; Q14CE0; Q8IWT2; Q8IZE4; Q8IZE5; Q8IZE6; Q8IZE7; B1AWB3; B1AWB4; B1AWB6; B1AWB7
• Molecular Weight: 98,720 Da
• NCBI Official Full Name: G-protein coupled receptor 64 isoform 4
• NCBI Official Synonym Full Names: G protein-coupled receptor 64
• NCBI Official Symbol: GPR64
• NCBI Official Synonym Symbols: HE6; EDDM6; TM7LN2
• NCBI Protein Information: G-protein coupled receptor 64; epididymal protein 6; human epididymis-specific protein 6; G protein-coupled receptor, epididymis-specific (seven transmembrane family)
• UniProt Protein Name: G-protein coupled receptor 64
• UniProt Gene Name: GPR64
• UniProt Synonym Gene Names: HE6; TM7LN2; He6
• UniProt Entry Name: GPR64_HUMAN

NCBI Description

This gene encodes a member of the G protein-coupled receptor family described as an epididymis-specific transmembrane protein. The encoded protein may be proteolytically processed as it contains a motif shown to be a protein scission motif in some members of this family (PMID: 11973329). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Uniprot Description

GPR64: Could be involved in a signal transduction pathway controlling epididymal function and male fertility. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 9 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; GPCR, family 2; Membrane protein, integral; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xp22.13

Cellular Component: cell surface; integral to plasma membrane; apical plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; spermatogenesis