Rabbit anti-Human, Mouse GPR61 Polyclonal Antibody | anti-GPR61 antibody

GPR61 Antibody

Cat. Num. AAA9604269

• Gene Names: GPR61; BALGR; GPCR3
• Reactivity: Human, Mouse
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: GPR61; Polyclonal Antibody; GPR61 Antibody; BALGR; Biogenic amine receptor like G protein coupled receptor; Biogenic amine receptor-like G-protein coupled receptor; G protein coupled receptor 61; GPCR3; Gpr61; GPR61_HUMAN; Probable G-protein coupled receptor 61; anti-GPR61 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GPR61 antibody detects endogenous levels of total GPR61
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 451

• Applicable Applications for anti-GPR61 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:2000
• Immunogen: A synthesized peptide
• Subcellular Location: Cell Membrane
• Tissue Specificity: Expressed in brain; detected in frontal and temporal lobes, occipital pole, amygdala and hippocampus (PubMed:11690637, PubMed:29226084). Also expressed in testis (PubMed:11690637, PubMed:29226084) and T cells, B cells, and monocyte (PubMed:29226084). Low expression in many other tissues (PubMed:11690637, PubMed:29226084). Widely expressed in the hippocampus (at protein level).
• Conjugation: Unconjugated

Western Blot (WB)

(Western blot analysis of GPR61 expression in A431 cell lysate, The lane on the left is treated with the antigen-specific peptide.)

Related Product Information for anti-GPR61 antibody

Function: Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight (By similarity).
Subunit Structure: Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR61 in the endosomal compartment (PubMed:28827538).
Similarity: Belongs to the G-protein coupled receptor 1 family.

NCBI and Uniprot Product Information

• NCBI GI #: 57165371
• NCBI GeneID: 83873
• NCBI Accession #: NP_114142.3
• NCBI GenBank Nucleotide #: NM_031936.4
• UniProt Accession #: Q9BZJ8; Q6NWS0; Q8TDV4; Q96PR4; A8K1W2
• Molecular Weight: Observed: 49 kDa; Predicted: 50 kDa
• NCBI Official Full Name: G-protein coupled receptor 61
• NCBI Official Synonym Full Names: G protein-coupled receptor 61
• NCBI Official Symbol: GPR61
• NCBI Official Synonym Symbols: BALGR; GPCR3
• NCBI Protein Information: G-protein coupled receptor 61
• UniProt Protein Name: G-protein coupled receptor 61
• Protein Family: Probable G-protein coupled receptor
• UniProt Gene Name: GPR61
• UniProt Synonym Gene Names: BALGR1 PublicationManual assertion based on opinion iniRef.2

NCBI Description

This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]

Uniprot Description

Orphan G-protein coupled receptor. Constitutively activates the G(s)-alpha/cAMP signaling pathway (PubMed:28827538). Shows a reciprocal regulatory interaction with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538). May be involved in the regulation of food intake and body weight ().