Rabbit anti-Human GPR62 Polyclonal Antibody | anti-GPR62 antibody

GPR62 Antibody

Cat. Num. AAA9606427

• Gene Names: GPR62; GPCR8; KPG_005
• Reactivity: Human
• Applications: Western Blot, ELISA
• Purity: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Synonyms: GPR62; Polyclonal Antibody; GPR62 Antibody; G protein coupled receptor GPCR8; G protein coupled receptor KPG_005; G protein-coupled receptor 62; G-protein coupled receptor GPCR8; G-protein coupled receptor KPG_005; GPCR8; GPR62_HUMAN; hGPCR8; KPG_005; MGC26943; Probable G protein coupled receptor 62; Probable G-protein coupled receptor 62; anti-GPR62 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GPR62 antibody detects endogenous levels of total GPR62
• Purity/Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
• Form/Format: Liquid; Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 368

• Applicable Applications for anti-GPR62 antibody: Western Blot (WB), ELISA (EIA)
• Application Notes: WB: 1:500-1:1000
• Immunogen: A synthesized peptide
• Subcellular Location: Endosome; Plasma Membrane
• Tissue Specificity: Expressed in brain; detected in the basal forebrain, frontal cortex, caudate, putamen, thalamus and hippocampus.
• Conjugation: Unconjugated
• Preparation and Storage: Store at -20 degree C. Stable for 12 months from date of receipt.

Western Blot (WB)

(Western blot analysis of extracts from COLO cells, using GPR62 antibody.)

Related Product Information for anti-GPR62 antibody

Function: Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).
Subunit Structure: Homodimers (By similarity). Forms heterodimer with MTNR1B (PubMed:28827538). Interacts with ARRB1 and ARRB2 in a spontaneous and agonist-independent manner; leading to the internalization of GPR62 in the endosomal compartment (PubMed:28827538).
Similarity: Lacks the conserved DRY and BBXXB motifs. The restoration of these motifs affects its constitutive activity. Belongs to the G-protein coupled receptor 1 family.

NCBI and Uniprot Product Information

• NCBI GI #: 145309315
• NCBI GeneID: 118442
• NCBI Accession #: NP_543141.3
• NCBI GenBank Nucleotide #: NM_080865.3
• UniProt Accession #: Q9BZJ7; Q5KU27; F1DAM4
• Molecular Weight: Observed: 38 kD; Predicted: 38 kDa
• NCBI Official Full Name: G-protein coupled receptor 62
• NCBI Official Synonym Full Names: G protein-coupled receptor 62
• NCBI Official Symbol: GPR62
• NCBI Official Synonym Symbols: GPCR8; KPG_005
• NCBI Protein Information: G-protein coupled receptor 62
• UniProt Protein Name: G-protein coupled receptor 62
• Protein Family: Probable G-protein coupled receptor
• UniProt Gene Name: GPR62
• UniProt Synonym Gene Names: hGPCR8

Uniprot Description

Orphan G-protein coupled receptor. Constitutively activates the G(q/11)/inositol phosphate and the G(s)-alpha/cAMP signaling pathways (PubMed:28827538). Has spontaneous activity for beta-arrestin recruitment (PubMed:28827538). Shows a reciprocal modulation of signaling functions with the melatonin receptor MTNR1B most likely through receptor heteromerization (PubMed:28827538).