Rabbit anti-Human, Rat GPR162 Polyclonal Antibody | anti-GPR162 antibody

GPR162 polyclonal antibody

Cat. Num. AAA3014852

• Gene Names: MYBPC1; LCCS4; MYBPCC; MYBPCS
• Reactivity: Human, Rat
• Applications: Western Blot
• Purity: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Synonyms: GPR162; Polyclonal Antibody; GPR162 polyclonal antibody; Myosin-binding protein C; slow-type; Slow MyBP-C; C-protein; skeletal muscle slow isoform; MYBPC1; MYBPCS; anti-GPR162 antibody

• Host: Rabbit
• Reactivity: Human, Rat
• Clonality: Polyclonal
• Isotype: Rabbit IgG
• Specificity: MYBPC1 polyclonal antibody detects endogenous levels of MYBPC1 protein.
• Purity/Purification: The protein was purified from E Coli and the purity is >95% (by SDS-PAGE)
• Form/Format: PBS with 0.02% sodium azide, 50% glycerol, pH7.4
• Concentration: 1mg/ml (varies by lot)

• Applicable Applications for anti-GPR162 antibody: Western Blot (WB)
• Application Notes: WB: 1:500~1000
• Immunogen: Synthetic peptide, corresponding to Human MYBPC1
• Preparation and Storage: Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze-thaw cycles.

Western Blot (WB)

(Western blot (WB) analysis of MYBPC1 polyclonal antibody at 1:500 dilutionLaneA: Hela whole cell lysateLaneB: PC12 whole cell lysate)

Related Product Information for anti-GPR162 antibody

MYBPC1, also known as MYBPCS (myosin-binding protein C, slow-type) or MyBP-C, is a 1,141 amino acid protein that contains 3 fibronectin type-III domains and 7 Ig-like C2-type domains. Existing as a member of the immunoglobulin superfamily, MYBPC1 functions as a thick filament-associated protein that localizes to striated muscle bands in vertebrae and is thought to modify the activity of select ATPases. Additionally, MYBPC1 may play a role in the modulation of muscle contraction and in the overall structural integrity of the cell. The gene encoding MYBPC1 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.

NCBI and Uniprot Product Information

• NCBI GI #: 45976288
• NCBI GeneID: 4604
• NCBI Accession #: NP_002456.2
• NCBI GenBank Nucleotide #: NM_002465.3
• UniProt Accession #: Q00872; Q15497; Q569K7; Q86T48; Q86TC8; Q8N3L2; G3XAE8
• Molecular Weight: 128,294 Da
• NCBI Official Full Name: myosin-binding protein C, slow-type isoform 1
• NCBI Official Synonym Full Names: myosin binding protein C, slow type
• NCBI Official Symbol: MYBPC1
• NCBI Official Synonym Symbols: LCCS4; MYBPCC; MYBPCS
• NCBI Protein Information: myosin-binding protein C, slow-type; slow MyBP-C; skeletal muscle C-protein; C-protein, skeletal muscle slow isoform
• UniProt Protein Name: Myosin-binding protein C, slow-type
• Protein Family: Probable G-protein coupled receptor
• UniProt Gene Name: MYBPC1
• UniProt Synonym Gene Names: MYBPCS; Slow MyBP-C
• UniProt Entry Name: MYPC1_HUMAN

NCBI Description

This gene encodes a member of the myosin-binding protein C family. Myosin-binding protein C family members are myosin-associated proteins found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The encoded protein is the slow skeletal muscle isoform of myosin-binding protein C and plays an important role in muscle contraction by recruiting muscle-type creatine kinase to myosin filaments. Mutations in this gene are associated with distal arthrogryposis type I. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

Uniprot Description

MYBPC1: Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. Defects in MYBPC1 are the cause of arthrogryposis, distal, type 1B (DA1B). A form of distal arthrogryposis, a disease characterized by congenital joint contractures that mainly involve two or more distal parts of the limbs, in the absence of a primary neurological or muscle disease. Distal arthrogryposis type 1 is characterized largely by camptodactyly and clubfoot. Hypoplasia and/or absence of some interphalangeal creases is common. The shoulders and hips are less frequently affected. Defects in MYBPC1 may be a cause of autosomal recessive lethal congenital contractural syndrome (LCCS), a severe, neonatally lethal form of arthrogryposis. Belongs to the immunoglobulin superfamily. MyBP family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Actin-binding; Myosin-binding

Chromosomal Location of Human Ortholog: 12q23.2

Cellular Component: myofibril; cytosol

Molecular Function: protein binding; structural constituent of muscle; titin binding; actin binding

Biological Process: cell adhesion; muscle filament sliding

Disease: Lethal Congenital Contracture Syndrome 4; Arthrogryposis, Distal, Type 1b