Rabbit GNB2L1 Polyclonal Antibody | anti-GNB2L1 antibody

GNB2L1 Polyclonal Antibody

Cat. Num. AAA2526196

• Gene Names: GNB2L1; H12.3; HLC-7; PIG21; RACK1; Gnb2-rs1
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Antigen affinity purification
• Synonyms: GNB2L1; Polyclonal Antibody; GNB2L1 Polyclonal Antibody; H12.3; HLC-7; PIG21; RACK1; Gnb2-rs1; anti-GNB2L1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Antigen affinity purification
• Concentration: 1.9mg/mL (varies by lot)
• Sequence Length: 317

• Applicable Applications for anti-GNB2L1 antibody: ELISA (EIA), Western Blot (WB)
• Application Notes: WB: 1:200-1:1000
• Immunogen: Recombinant protein of human GNB2L1
• Buffer: PBS with 0.05% sodium azide, 50% glycerol, pH7.3
• Preparation and Storage: Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.

Western Blot (WB)

(Western Blot analysis of NIH/3T3 and Jurkat cell using GNB2L1 Polyclonal Antibody at dilution of 1:300)

Related Product Information for anti-GNB2L1 antibody

RACK1 (receptor for activated C kinase 1) is a 317 amino acid G protein b subunit-like protein that functions as a RACK and inhibits the activity of Src tyrosine kinases. In response to PKC activation, the intracellular localization of RACK1 and PKC bII changes, and RACK1 and PKC bII co-localize to the same sites. RACK1 is therefore thought to be a shuttling protein for PKC bII. A deficit in RACK1 may be associated with impaired PKC activation in the aging brain.

Product Categories/Family for anti-GNB2L1 antibody

Cell Biology

NCBI and Uniprot Product Information

• NCBI GI #: 49456773
• NCBI GeneID: 10399
• UniProt Accession #: P63244; P25388; P99049; Q53HU2; Q5J8M6; Q5VLR4; Q6FH47; B3KTJ0; D3DWS0
• Molecular Weight: 35,077 Da
• NCBI Official Full Name: GNB2L1, partial
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
• NCBI Official Symbol: GNB2L1
• NCBI Official Synonym Symbols: H12.3; HLC-7; PIG21; RACK1; Gnb2-rs1
• NCBI Protein Information: guanine nucleotide-binding protein subunit beta-2-like 1; cell proliferation-inducing gene 21 protein; guanine nucleotide binding protein beta polypeptide 2-like 1; guanine nucleotide-binding protein subunit beta-like protein 12.3; human lung cancer oncogene 7 protein; protein homologous to chicken B complex protein, guanine nucleotide binding; receptor for activated C kinase 1; receptor of activated protein kinase C 1
• UniProt Protein Name: Guanine nucleotide-binding protein subunit beta-2-like 1
• UniProt Gene Name: GNB2L1
• UniProt Synonym Gene Names: HLC-7; RACK1
• UniProt Entry Name: GBLP_HUMAN

Uniprot Description

RACK1: a G-beta like protein containing 7 WD domains. A presumptive scaffold protein, linking protein kinase C to its substrates. Binds inositol 1,4,5-trisphosphate receptors and regulates Ca2+ release by enhancing inositol 1,4,5-trisphosphate receptor binding affinity for inositol 1,4,5-trisphosphate. An insulin-like growth factor 1 receptor-interacting protein that can regulate IGF-1-mediated Akt activation and protection from cell death.

Protein type: G protein; Nuclear receptor co-regulator; Adaptor/scaffold; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 5q35.3

Cellular Component: small ribosomal subunit; cytoskeleton; cell soma; mitochondrion; perinuclear region of cytoplasm; cytoplasm; dendrite; perikaryon; midbody; cytosol; nucleus; phagocytic cup

Molecular Function: protein tyrosine kinase inhibitor activity; protein binding; protein homodimerization activity; enzyme binding; protein kinase C binding; SH2 domain binding; caspase activator activity; protein complex scaffold; receptor tyrosine kinase binding; protein phosphatase binding; ion channel inhibitor activity; receptor binding

Biological Process: caspase activation; negative regulation of phagocytosis; negative regulation of Wnt receptor signaling pathway; negative regulation of protein kinase B signaling cascade; viral reproduction; regulation of cell cycle; positive regulation of apoptosis; positive regulation of protein homooligomerization; rhythmic process; gastrulation; cell cycle; osteoblast differentiation; regulation of protein localization; positive regulation of mitochondrial depolarization; negative regulation of translation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of cAMP catabolic process; positive regulation of cyclic-nucleotide phosphodiesterase activity; negative regulation of cell growth; positive regulation of protein amino acid phosphorylation; regulation of cell division; positive regulation of cell migration; positive regulation of GTPase activity