Rabbit anti-Human GNAQ Polyclonal Antibody | anti-GNAQ antibody

Rabbit Polyclonal to Human GNAQ

Cat. Num. AAA248089

• Gene Names: GNAQ; GAQ; SWS; CMC1; G-ALPHA-q
• Reactivity: Human
• Applications: Immunohistochemistry, Western Blot
• Purity: Immunoaffinity Purified
• Synonyms: GNAQ; Polyclonal Antibody; Rabbit Polyclonal to Human GNAQ; Anti-GNAQ Antibody (aa51-78) IHC-plus; G-ALPHA-q; GAQ; Human GNAQ; anti-GNAQ antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: Human GNAQ
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.09% sodium azide
• Sequence Length: 359

• Applicable Applications for anti-GNAQ antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (10 ug/ml), WB (1:1000)
• Target Species: Human
• Immunogen Description: KLH-conjugated synthetic peptide from N-terminal region of human GNAQ.
• Immunogen Type: Synthetic peptide
• Immunogen: GNAQ antibody was raised against kLH-conjugated synthetic peptide from N-terminal region of human GNAQ.
• Antigen Modification: aa51-78
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Immunohistochemistry (IHC)

(Anti-GNAQ antibody IHC staining of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.)

Western Blot (WB)

(GNAQ Antibody (N-term) Western blot of human placenta tissue lysates (35 ug/lane). This demonstrates the GNAQ antibody detected the GNAQ protein (arrow).)

Western Blot (WB)

(Western blot of GNAQ (arrow) using rabbit polyclonal GNAQ Antibody (N-term). 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the GNAQ gene.)

Related Product Information for anti-GNAQ antibody

Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GTP for GDP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors.

NCBI and Uniprot Product Information

• NCBI GI #: 40254462
• NCBI GeneID: 2776
• NCBI Accession #: NP_002063.2
• NCBI GenBank Nucleotide #: NM_002072.4
• UniProt Accession #: P50148; O15108; Q13462; Q6NT27; Q92471; Q9BZB9
• Molecular Weight: 42,142 Da
• NCBI Official Full Name: guanine nucleotide-binding protein G(q) subunit alpha
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), q polypeptide
• NCBI Official Symbol: GNAQ
• NCBI Official Synonym Symbols: GAQ; SWS; CMC1; G-ALPHA-q
• NCBI Protein Information: guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein G(q) subunit alpha; guanine nucleotide-binding protein alpha-q
• UniProt Protein Name: Guanine nucleotide-binding protein G(q) subunit alpha
• UniProt Gene Name: GNAQ
• UniProt Synonym Gene Names: GAQ
• UniProt Entry Name: GNAQ_HUMAN

NCBI Description

This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]

Uniprot Description

G-alpha(q): a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Agonist binding to Gq-coupled receptors may block Akt activation via the release of active G-alpha(q) subunits that inhibit phosphatidylinositol 3-kinase. Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site.

Protein type: G protein; G protein, heterotrimeric alpha G(q); G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 9q21

Cellular Component: nuclear membrane; lysosomal membrane; cytoplasm; plasma membrane; heterotrimeric G-protein complex

Molecular Function: GTPase activity; signal transducer activity; protein binding; GTP binding; type 2A serotonin receptor binding; metal ion binding; G-protein beta/gamma-subunit binding; GTPase activator activity

Biological Process: platelet activation; regulation of action potential; protein stabilization; maternal behavior; metabolic process; glutamate signaling pathway; heart development; pigmentation during development; G-protein signaling, adenylate cyclase activating pathway; post-embryonic development; regulation of melanocyte differentiation; forebrain neuron development; phospholipase C activation; negative regulation of protein kinase activity; embryonic digit morphogenesis; dopamine receptor, phospholipase C activating pathway; blood coagulation; skeletal development; neuron remodeling; positive regulation of GTPase activity

Disease: Sturge-weber Syndrome; Capillary Malformations, Congenital