Rabbit GNA13 Polyclonal Antibody | anti-GNA13 antibody

GNA13 Polyclonal Antibody

Cat. Num. AAA3011322

• Gene Names: GNA13; G13
• Reactivity: Human, Mouse, Rat
• Applications: Western Blot, Immunohistochemistry, Immunofluorescence
• Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Synonyms: GNA13; Polyclonal Antibody; GNA13 Polyclonal Antibody; G alpha 13; G-protein subunit alpha-13; Guanine nucleotide binding protein alpha 13 subunit; Galpha 13; Galpha13; anti-GNA13 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: GNA13 polyclonal antibody detects endogenous levels of GNA13 protein.
• Purity/Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
• Form/Format: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
• Sequence Length: 282

• Applicable Applications for anti-GNA13 antibody: Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
• Application Notes: WB: 1:500-1:2000; IHC: 1:100-1:200; IF: 1:100-1:200
• Immunogen: Recombinant full length Human GNA13.
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Western Blot (WB)

(Western Blot (WB) analysis of GNA13 polyclonal antibody)

Related Product Information for anti-GNA13 antibody

Gamma-glutamyltranspeptidase (GGT) acts as a glutathionase and catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. This enzyme is located on the outer surface of the cell membrane and is widely distributed in mammalian tissues involved in absorption and secretion. In humans, hepatic GGT activity is elevated in some liver diseases. GGT1 is released into the bloodstream after liver damage, and an elevated level of the enzyme may be a useful early sign of hepatocellular carcinoma. GGT5 converts leukotriene C4 to leukotriene D4; it does not, however, convert synthetic substrates that are commonly used to assay GGT. In human serum and in human tissues, there is a marked heterogeneity in GGT, but this heterogeneity can be attributed to different glycosylation of the same peptide rather than to the products of different genes.

NCBI and Uniprot Product Information

• NCBI GI #: 540344574
• NCBI GeneID: 10672
• NCBI Accession #: NP_001269354.1
• NCBI GenBank Nucleotide #: NP_001269354.1
• UniProt Accession #: Q14344
• Molecular Weight: ~ 44kDa
• NCBI Official Full Name: guanine nucleotide-binding protein subunit alpha-13 isoform 2
• NCBI Official Synonym Full Names: G protein subunit alpha 13
• NCBI Official Symbol: GNA13
• NCBI Official Synonym Symbols: G13
• NCBI Protein Information: guanine nucleotide-binding protein subunit alpha-13
• UniProt Protein Name: Guanine nucleotide-binding protein subunit alpha-13
• Protein Family: Guanine nucleotide-binding protein
• UniProt Gene Name: GNA13
• UniProt Synonym Gene Names: G alpha-13; G-protein subunit alpha-13
• UniProt Entry Name: GNA13_HUMAN

Uniprot Description

G-alpha 13: a guanine nucleotide-binding protein of the G12 class of G-alpha proteins. Activates Rho. Protein kinase A blocks Rho activation by phosphorylation of G-alpha(13). Heterotrimeric G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Regulates cytoplasmic as well as nuclear signaling events such as activation of the Jun N-terminal kinase signaling module, Na+/H+ exchangers, focal adhesion assemblies, and transcriptional activation of specific primary response genes.

Protein type: G protein, heterotrimeric alpha G(12); G protein; G protein, heterotrimeric

Chromosomal Location of Human Ortholog: 17q24.3

Cellular Component: focal adhesion; membrane; brush border membrane; plasma membrane; melanosome; heterotrimeric G-protein complex; nucleus

Molecular Function: GTPase activity; signal transducer activity; protein binding; GTP binding; metal ion binding; G-protein beta/gamma-subunit binding; type 1 angiotensin receptor binding; D5 dopamine receptor binding

Biological Process: phospholipase D activation; platelet activation; metabolic process; in utero embryonic development; signal transduction; G-protein signaling, adenylate cyclase activating pathway; regulation of cell migration; Rho protein signal transduction; patterning of blood vessels; regulation of cell shape; elevation of cytosolic calcium ion concentration; blood coagulation; cell differentiation; cell motility