Rabbit Glucose Transporter 2 (GLUT2) Polyclonal Antibody | anti-GLUT2 antibody

Glucose Transporter 2 (GLUT2) Polyclonal Antibody

Cat. Num. AAA191357

• Gene Names: SLC2A2; GLUT2
• Applications: Immunoblot, Western Blot, Immunofluorescence
• Synonyms: Glucose Transporter 2 (GLUT2); Polyclonal Antibody; Glucose Transporter 2 (GLUT2) Polyclonal Antibody; anti-GLUT2 antibody

• Host: Rabbit
• Clonality: Polyclonal
• Specificity: This antibody recognizes human and rat GLUT2..
• Form/Format: 100ug (1mg/ml) peptide affinity-purified antibody in PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.
• Sequence Length: 524

• Applicable Applications for anti-GLUT2 antibody: Immunoblot, Immunofluorescence (IF)
• Application Notes: Immunoblot: 1:1,000; A bands of 57~kDa is detected. Bands of ~72kDa and ~37kDa may also be detected.; IF: 1:100
• Immunogen: Synthetic peptide corresponding to the C-terminus of human GLUT2.

Testing Data

(Detection of GLUT2 in rat liver lysate diluted 1:1,000.)

Testing Data

(Detection of GLUT2 in HeLa cell lysate (left) and human 293T cell lysate (right) diluted 1:1,000.)

Testing Data

(Detection of GLUT2 in human Colon cancer cell line (HT-29) diluted 1:100. DAPI (blue) nuclear stain, Texas red actin stain, and FITC (green) BDNF stain.)

Related Product Information for anti-GLUT2 antibody

GLUT2 is a member of the human glucose transport protein family. It is present in high concentration in the plasma membrane of pancreatic b-cells where it initiates the first step in glucose-stimulated insulin secretion. GLUT2 is required for glucose sensitivity in the hypothalamus and brain stem and is involved in control of food intake and stimulation of glucose uptake by peripheral tissues.

NCBI and Uniprot Product Information

• NCBI GI #: 4557851
• NCBI GeneID: 6514
• NCBI Accession #: NP_000331.1
• NCBI GenBank Nucleotide #: NM_000340.1
• UniProt Accession #: P1168; Q9UCW9; A8K481; B2R936; B7Z547; F8W8V8; P11168
• Molecular Weight: 44,702 Da
• NCBI Official Full Name: solute carrier family 2, facilitated glucose transporter member 2 isoform 1
• NCBI Official Synonym Full Names: solute carrier family 2 member 2
• NCBI Official Symbol: SLC2A2
• NCBI Official Synonym Symbols: GLUT2
• NCBI Protein Information: solute carrier family 2, facilitated glucose transporter member 2
• UniProt Protein Name: Solute carrier family 2, facilitated glucose transporter member 2
• UniProt Gene Name: SLC2A2
• UniProt Synonym Gene Names: GLUT2; GLUT-2

NCBI Description

This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

Uniprot Description

Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na+/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney.