Western Blot (WB)
(Detection of Human, Mouse, and Rat GLRX3 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, NIH3T3 mouse embryonic fibroblast cell line, and H4IIEC3 rat hepatoma cell line. PVDF membrane was probed with 1ug/ml of Sheep Human GLRX3 Affinity purified Polyclonal followed by HRP-conjugated Sheep IgG Secondary. A specific band was detected for Glutaredoxin 3/GLRX3 at approximately 40kD (as indicated).)
Sheep GLRX3 Polyclonal Antibody | anti-GLRX3 antibody
GLRX3 (Glutaredoxin-3, PKC-interacting Cousin of Thioredoxin, PICOT, PKC-theta-interacting Protein, PKCq-interacting Protein, Thioredoxin-like Protein 2, PICOT, TXNL2, HUSSY-22)
Purified by immunoaffinity chromatography.
Purified by immunoaffinity chromatography.
Dilution: Western Blot: 1ug/ml
Western Blot (WB)
(Detection of Human, Mouse, and Rat GLRX3 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, NIH3T3 mouse embryonic fibroblast cell line, and H4IIEC3 rat hepatoma cell line. PVDF membrane was probed with 1ug/ml of Sheep Human GLRX3 Affinity purified Polyclonal followed by HRP-conjugated Sheep IgG Secondary. A specific band was detected for Glutaredoxin 3/GLRX3 at approximately 40kD (as indicated).)
Western Blot (WB)
(Detection of Human, Mouse, and Rat GLRX3 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line, NIH3T3 mouse embryonic fibroblast cell line, and H4IIEC3 rat hepatoma cell line. PVDF membrane was probed with 1ug/ml of Sheep Human GLRX3 Affinity purified Polyclonal followed by HRP-conjugated Sheep IgG Secondary. A specific band was detected for Glutaredoxin 3/GLRX3 at approximately 40kD (as indicated).)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Uniprot Description
GLRX3: Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: cell cortex; Z disc
Molecular Function: protein binding; electron carrier activity; protein kinase C binding; metal ion binding; protein disulfide oxidoreductase activity; iron-sulfur cluster binding
Biological Process: cell redox homeostasis; regulation of the force of heart contraction
Research Articles on GLRX3
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Product Notes
The GLRX3 glrx3 (Catalog #AAA644475) is an Antibody produced from Sheep and is intended for research purposes only. The product is available for immediate purchase. The GLRX3 (Glutaredoxin-3, PKC-interacting Cousin of Thioredoxin, PICOT, PKC-theta-interacting Protein, PKCq-interacting Protein, Thioredoxin-like Protein 2, PICOT, TXNL2, HUSSY-22) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GLRX3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Suitable for use in Western Blot. Dilution: Western Blot: 1ug/ml. Researchers should empirically determine the suitability of the GLRX3 glrx3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GLRX3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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