Western Blot (WB)
(Western blot analysis of GLRB expression in HeLa (A), NIH3T3 (B), rat spleen (C) whole cell lysates.)
Rabbit GLRB Polyclonal Antibody | anti-GLRB antibody
Anti-GLRB Antibody
Western Blot (WB)
(Western blot analysis of GLRB expression in HeLa (A), NIH3T3 (B), rat spleen (C) whole cell lysates.)
Western Blot (WB)
(Western blot analysis of GLRB expression in HeLa (A), NIH3T3 (B), rat spleen (C) whole cell lysates.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Description
GLRB: The glycine receptor is a neurotransmitter-gated ion channel. Binding of glycine to its receptor increases the chloride conductance and thus produces hyperpolarization (inhibition of neuronal firing). Defects in GLRB are the cause of hyperekplexia type 2 (HKPX2). HKPX2 is a neurologic disorder characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile2 stimuli. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRB sub- subfamily.
Protein type: Transporter, ion channel; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Channel, ligand-gated
Chromosomal Location of Human Ortholog: 4q31.3
Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction
Molecular Function: protein binding; extracellular-glycine-gated chloride channel activity; extracellular-glycine-gated ion channel activity; glycine binding; drug binding
Biological Process: nervous system development; startle response; synaptic transmission, glycinergic; righting reflex; protein heterooligomerization; acrosome reaction; adult walking behavior; synaptic transmission; regulation of membrane potential; visual perception; neuropeptide signaling pathway; ion transport; transmembrane transport
Disease: Hyperekplexia 2
Research Articles on GLRB
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Product Notes
The GLRB glrb (Catalog #AAA821805) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GLRB Antibody reacts with Human, Mouse, Rat, Bovine, Pig and may cross-react with other species as described in the data sheet. AAA Biotech's GLRB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB (1/500 - 1/1000). Researchers should empirically determine the suitability of the GLRB glrb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GLRB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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