Structure
8-pCPT-2-O-Me-cAMP-AM Activator
8-pCPT-2-O-Me-cAMP-AM
Purity
>97% (HPLC)
Synonyms
8-pCPT-2-O-Me-cAMP-AM; 8-(4-Chlorophenylthio)-2'-O-methyladenosine-3'; 5'-cyclic monophosphate acetoxymethyl ester; 8-pCPT-2-O-Me-cAMP-AM activator
Purity/Purification
>97% (HPLC)
Specific Activity
Epac Pathway, RAP1 Pathway Activator
CAS Registry Number
1152197-23-3
Molecular Formula
C20H21ClN5O8PS
Solubility
May be dissolved in DMSO (50mg/ml). Poorly soluble in aqueous solution.
Preparation and Storage
Store desiccated as supplied at -20 degree C for up to 2 years. Store solutions at -20 degree C for up to 1 month.
Structure
Structure
Related Product Information for 8-pCPT-2-O-Me-cAMP-AM activator
A potent, cell permeable Epac (exchange protein directly activated by cAMP) activator (1). Induces RAP1 activation and insulin secretion in pancreatic beta cell lines (2-5). Induces vascular relaxation in rate mesenteric artery (6). The acetoxymethyl ester confers increased cell-permeability and is cleaved by endogenous esterases to yield the active compound, 8-pCPT-2'-O-Me-cAMP. Addition to cell cultures should be done in serum-free media as esterases in the serum will cleave the acetoxymethyl ester and reduce cell permeability.
Product Categories/Family for 8-pCPT-2-O-Me-cAMP-AM activator
References
1. MJ Vliem et al. Chembiochem. Sci.2008 9:2052.
2. OG Chepurny et al. J. Biol. Chem. 2009 284:10726.
3. GG Kelley et al. Islets 2009 1:260.
4. OG Chepurny et al. Am. J. Physiol. Edocrinol. Metab. 2010 298:E622.
5. I Dzhura et al Islets 2011 3:121.
6. OL Roberts et al. J. Physiol. 2013 591:5107.
2. OG Chepurny et al. J. Biol. Chem. 2009 284:10726.
3. GG Kelley et al. Islets 2009 1:260.
4. OG Chepurny et al. Am. J. Physiol. Edocrinol. Metab. 2010 298:E622.
5. I Dzhura et al Islets 2011 3:121.
6. OL Roberts et al. J. Physiol. 2013 591:5107.
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Product Notes
The 8-pCPT-2-O-Me-cAMP-AM (Catalog #AAA515789) is an Activator and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "8-pCPT-2-O-Me-cAMP-AM, Activator" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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