Western Blot/Blotting
(Western blot analysis)
Rabbit GFRa-2 (GDNFRb) (Neurturin receptor) Polyclonal Antibody | anti-GFRa-2 antibody
GFRa-2 (IN) (GDNFRb) (Neurturin receptor)
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Antigen Immunoaffiinity Purification
Synonyms
GFRa-2 (GDNFRb) (Neurturin receptor); Polyclonal Antibody; GFRa-2 (IN) (GDNFRb) (Neurturin receptor); Rabbit anti-Glial Cell Derived Neurotrophic Factor Receptor -2 (Second Intracellular Loop); Human; Mouse; Rat; anti-GFRa-2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Antigen Immunoaffiinity Purification
Form/Format
Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative
Sequence Length
463
Applicable Applications for anti-GFRa-2 antibody
Western Blot (WB)
Immunogen
Synthetic peptide corresponding to amino acids 377 to 391 of human GFR -2. This sequence is identical to those of the mouse and rat.
Positive Control
HeLa whole cell lysate
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Western Blot/Blotting
(Western blot analysis)
Western Blot/Blotting
(Western blot analysis)
Related Product Information for anti-GFRa-2 antibody
Members of the glial cell line-derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN)1, play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNR, which is a cell surface receptor for NTN2,3. The cDNAs encoding NTNR from human, rat, chicken, and mouse have been cloned recently2-7. NTNR was also termed GDNFR, Ret ligand 2 (RETL2) or TGF- -related neurotrophic factor receptor 2 (TrnR2)4-7 and nominated as GFR -2 recently8. GFR -2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFR -2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.
Product Categories/Family for anti-GFRa-2 antibody
NCBI and Uniprot Product Information
NCBI GI #
UniProt Accession #
Molecular Weight
52
NCBI Official Full Name
GDNF family receptor alpha-2
UniProt Protein Name
GDNF family receptor alpha-2
UniProt Gene Name
Gfra2
UniProt Synonym Gene Names
Gdnfrb; Trnr2; GDNF receptor alpha-2; GDNFR-alpha-2; GFR-alpha-2; GDNFR-beta; NRTNR-alpha; NTNR-alpha
UniProt Entry Name
GFRA2_MOUSE
Uniprot Description
Function: Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor
By similarity.
Tissue specificity: Neurons of the superior cervical and dorsal root ganglia, and adult brain and testis. Low level in the spleen and in the adrenal gland.
Sequence similarities: Belongs to the GDNFR family.
Similar Products
Product Notes
The GFRa-2 gfra2 (Catalog #AAA395607) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GFRa-2 (IN) (GDNFRb) (Neurturin receptor) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GFRa-2 (GDNFRb) (Neurturin receptor) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the GFRa-2 gfra2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GFRa-2 (GDNFRb) (Neurturin receptor), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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