Western Blot/Blotting
(Western blot analysis)
Rabbit GFRa-1 (IN) (GDNFRa) (GDNF receptor) Polyclonal Antibody | anti-GFRa-1 antibody
GFRa-1 (IN) (GDNFRa) (GDNF receptor)
Gene Names
GFRA1; GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry
Purity
DEAE Purification
Synonyms
GFRa-1 (IN) (GDNFRa) (GDNF receptor); Polyclonal Antibody; Rabbit anti-Glial Cell Derived Neurotrophic Factor Receptor -1 (Second Intracellular Loop); Human; Mouse; Rat; anti-GFRa-1 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
DEAE Purification
Form/Format
Provided in phosphate buffered saline solution containing 0.02% sodium azide as a preservative
Sequence Length
460
Applicable Applications for anti-GFRa-1 antibody
Western Blot (WB), Iimmunohistochemistry (IHC)
Immunogen
Synthetic peptide corresponding to amino acids 369 to 382 of human GFR -1
Positive Control
Human brain tissue lysate
Preparation and Storage
Product should be stored at -20 degree C. Aliquot to avoid freeze/thaw cycles
Western Blot/Blotting
(Western blot analysis)
Western Blot/Blotting
(Western blot analysis)
Related Product Information for anti-GFRa-1 antibody
Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFR, which is a cell surface receptor for GDNF1,2. The cDNAs encoding GDNFR from human, rat, chicken and mouse have been cloned recently1-5. GDNFR was also termed Ret ligand 1 (RETL1) or TGF- -related neurotrophic factor receptor 1 (TrnR1) and nominated as GFR -1 recently5-7. GFR -1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase (PTK). Thus, GDNF, GFR and the Ret PTK form a complex to transduce GDNF signal and to mediate GDNF function.
Product Categories/Family for anti-GFRa-1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
51,456 Da
NCBI Official Full Name
GDNF family receptor alpha-1 isoform b preproprotein
NCBI Official Synonym Full Names
GDNF family receptor alpha 1
NCBI Official Symbol
GFRA1
NCBI Official Synonym Symbols
GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
NCBI Protein Information
GDNF family receptor alpha-1; RET ligand 1; GDNFR-alpha-1; GDNF receptor alpha-1; GPI-linked anchor protein; PI-linked cell-surface accessory protein; TGF-beta related neurotrophic factor receptor 1; TGF-beta-related neurotrophic factor receptor 1; Glial cell line-derived neurotrophic factor receptor alpha
UniProt Protein Name
GDNF family receptor alpha-1
UniProt Gene Name
GFRA1
UniProt Synonym Gene Names
GDNFRA; RETL1; TRNR1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1
UniProt Entry Name
GFRA1_HUMAN
NCBI Description
Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Feb 2009]
Uniprot Description
Function: Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor
By similarity.
Subunit structure: 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET
By similarity.
Subcellular location: Cell membrane; Lipid-anchor › GPI-anchor
By similarity.
Sequence similarities: Belongs to the GDNFR family.
Research Articles on GFRa-1
Similar Products
Product Notes
The GFRa-1 gfra1 (Catalog #AAA395940) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GFRa-1 (IN) (GDNFRa) (GDNF receptor) reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GFRa-1 (IN) (GDNFRa) (GDNF receptor) can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Iimmunohistochemistry (IHC). Researchers should empirically determine the suitability of the GFRa-1 gfra1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GFRa-1 (IN) (GDNFRa) (GDNF receptor), Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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