Rabbit GFR alpha Polyclonal Antibody | anti-GFR alpha antibody
GFR alpha antibody
Applications
Western Blot
Purity
GFR alpha antibody was purified by affinity chromatography
Synonyms
GFR alpha; Polyclonal Antibody; GFR alpha antibody; Polyclonal GFR alpha; anti-GFR alpha; Glial cell line derived neurotrophic factor; GFR-alpha; GFR-a; GFR a; GDNF; anti-GFR alpha antibody
Host
Rabbit
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
GFR alpha antibody was purified by affinity chromatography
Form/Format
Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal
Concentration
500 ug/ml (varies by lot)
Applicable Applications for anti-GFR alpha antibody
Western Blot (WB)
Application Notes
WB: 0.5-4 ug/ml
Biological Significance
Glial cell line-derived neurotrophic factor is a potent survival factor for central and peripheral neurons and is essential for the development of kidneys and the enteric nerves system. Physiological responses to GDNF require the presence of a novel glycosylphosphadidylinositol linked protein GDNFRalpha, which is a cell surface receptor for GDNF. The cDNA encoding GDNFRalpha from human, rat, chicken and mouse have been cloned recently. GDNFRalpha was also termed Ret ligand 1 or TGF-beta-related neurotrophic factor receptor 1 and nominated as GFRalpha-1 recently. GFRalpha-1 binds GDNF specifically and mediates activation of the Ret protein tyrosine kinase. Thus, GDNF, GFRalpha and the Ret PTK from a complex to transduce GDNF signal and to mediate GDNF function.
Cross-Reactivity
Human, Mouse, Rat
Immunogen
GFR alpha antibody was raised in Rabbit using synthetic Peptide to amino acids 369-382 of human GFR alpha-1 as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Related Product Information for anti-GFR alpha antibody
Rabbit polyclonal GFR alpha antibody
Product Categories/Family for anti-GFR alpha antibody
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Product Notes
The GFR alpha (Catalog #AAA835558) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's GFR alpha can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 0.5-4 ug/ml. Researchers should empirically determine the suitability of the GFR alpha for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GFR alpha, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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