Rabbit GEMIN2 Polyclonal Antibody | anti-GEMIN2 antibody

GEMIN2 (Gem-associated Protein 2, SIP1, SIP1-delta, SMN-interacting Protein 1) (HRP)

Cat. Num. AAA6418305

• Gene Names: GEMIN2; SIP1; SIP1-delta
• Reactivity: Human, Mouse, Rat
• Applications: Immunofluorescence, Western Blot, Immunohistochemistry
• Purity: Purified by affinity chromatography.
• Synonyms: GEMIN2; Polyclonal Antibody; GEMIN2 (Gem-associated Protein 2; SIP1; SIP1-delta; SMN-interacting Protein 1) (HRP); anti-GEMIN2 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GEMIN2. Species Crossreactivity: mouse, rat
• Purity/Purification: Purified by affinity chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Horseradish Peroxidase (HRP).

• Applicable Applications for anti-GEMIN2 antibody: Immunofluorescence (IF), Western Blot (WB), Immunohistochemistry (IHC)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Synthetic peptide corresponding to human GEMIN2.
• Conjugate: HRP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Note: Sodium azide is a potent inhibitor of peroxidase and should not be added to HRP conjugates. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunohistochemistry (IHC)

(Immunohistochemistry of paraffin-embedded human ovarian cancer tissue using 210979.)

Testing Data

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Testing Data

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Related Product Information for anti-GEMIN2 antibody

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.

Product Categories/Family for anti-GEMIN2 antibody

Antibodies; Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 6094289
• NCBI GeneID: 8487
• UniProt Accession #: O14893; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79; B2R9W8
• Molecular Weight: 280
• NCBI Official Full Name: Gem-associated protein 2
• NCBI Official Synonym Full Names: gem (nuclear organelle) associated protein 2
• NCBI Official Symbol: GEMIN2
• NCBI Official Synonym Symbols: SIP1; SIP1-delta
• NCBI Protein Information: gem-associated protein 2; gemin-2; component of gems 2; SMN interacting protein 1-delta; survival of motor neuron protein interacting protein 1
• UniProt Protein Name: Gem-associated protein 2
• Protein Family: Gem-associated protein
• UniProt Gene Name: GEMIN2
• UniProt Synonym Gene Names: SIP1; Gemin-2; SMN-interacting protein 1
• UniProt Entry Name: GEMI2_HUMAN

NCBI Description

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Uniprot Description

SIP1: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Belongs to the gemin-2 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; SMN complex; cytosol; nucleus

Molecular Function: protein binding

Biological Process: RNA splicing, via transesterification reactions; spliceosomal snRNP biogenesis; RNA splicing; spliceosome assembly; gene expression; mRNA processing