Rabbit TLX3 Polyclonal Antibody | anti-TLX3 antibody

Rabbit Polyclonal (IgG) to Human TLX3

Cat. Num. AAA248578

• Gene Names: TLX3; RNX; HOX11L2
• Reactivity: Human, Mouse, Rat
• Applications: Immunohistochemistry, Immunofluorescence, Western Blot, ELISA
• Purity: Immunoaffinity Purified
• Synonyms: TLX3; Polyclonal Antibody; Rabbit Polyclonal (IgG) to Human TLX3; Anti-TLX3 Antibody (N-Terminus) IHC-plus; Homeobox protein Hox-11L2; HOX11L2; Homeo box 11-like 2; RNX; T-cell leukemia homeobox 3; T-cell leukemia; homeobox 3; Human TLX3; anti-TLX3 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: TLX3 antibody is predicted to not cross-react with other TLX proteins.
• Purity/Purification: Immunoaffinity Purified
• Form/Format: PBS, 0.02% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 291

• Applicable Applications for anti-TLX3 antibody: Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
• Application Notes: ELISA, IF (20 ug/ml), IHC-P (10 ug/ml), WB (0.5 - 1 ug/ml)
• Target Species: Human
• Immunogen Description: 16 amino acid peptide near the amino terminus of human TLX3.
• Immunogen: TLX3 antibody was raised against 16 amino acid peptide near the amino terminus of human TLX3.
• Antigen Modification: N-Terminus
• Preparation and Storage: Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC)

(Anti-TLX3 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.)

Immunofluorescence (IF)

(Immunofluorescence of TLX3 in human spleen tissue with TLX3 antibody at 20 ug/ml.)

Western Blot (WB)

(Western blot analysis of TLX3 in human spleen tissue lysate with TLX3 antibody at (A) 0.5 and (B) 1 ug/ml.)

NCBI and Uniprot Product Information

• NCBI GI #: 50355978
• NCBI GeneID: 30012
• NCBI Accession #: NP_066305.2
• NCBI GenBank Nucleotide #: NM_021025.2
• UniProt Accession #: O43711; Q96AD3
• Molecular Weight: 31,867 Da
• NCBI Official Full Name: T-cell leukemia homeobox protein 3
• NCBI Official Synonym Full Names: T-cell leukemia homeobox 3
• NCBI Official Symbol: TLX3
• NCBI Official Synonym Symbols: RNX; HOX11L2
• NCBI Protein Information: T-cell leukemia homeobox protein 3; homeo box 11-like 2; homeobox protein Hox-11L2; T-cell leukemia, homeobox 3
• UniProt Protein Name: T-cell leukemia homeobox protein 3
• Protein Family: T-cell leukemia homeobox protein
• UniProt Gene Name: TLX3
• UniProt Synonym Gene Names: HOX11L2
• UniProt Entry Name: TLX3_HUMAN

NCBI Description

RNX (HOX11L2, TLX3) belongs to a family of orphan homeobox genes that encode DNA-binding nuclear transcription factors. Members of the HOX11 gene family are characterized by a threonine-47 replacing cytosine in the highly conserved homeodomain (Dear et al., 1993 [PubMed 8099440]).[supplied by OMIM, Mar 2008]

Uniprot Description

TLX3:

Protein type: Cell development/differentiation; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 5q35.1

Cellular Component: nucleus

Molecular Function: protein binding; sequence-specific DNA binding

Biological Process: negative regulation of neuron differentiation; central nervous system development; regulation of transcription, DNA-dependent; neuron migration; neuron fate specification; neurological control of breathing; respiratory gaseous exchange