Testing Data
(Sample (30 ug of whole cell lysate) A: A431 B: H1299 10% SDS PAGE Primary antibody diluted at 1: 1000)
Rabbit anti-Human GDP-mannose 4,6-dehydratase Polyclonal Antibody | anti-GMDS antibody
GDP-mannose 4,6-dehydratase antibody
Immunohistochemistry: 1:50-1:500
Testing Data
(Sample (30 ug of whole cell lysate) A: A431 B: H1299 10% SDS PAGE Primary antibody diluted at 1: 1000)
Testing Data
(Sample (30 ug of whole cell lysate) A: A431 B: H1299 10% SDS PAGE Primary antibody diluted at 1: 1000)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded DLD1 xenograft, using GMDS antibody at 1: 500 dilution.)
Immunohistochemistry (IHC)
(Immunohistochemical analysis of paraffin-embedded DLD1 xenograft, using GMDS antibody at 1: 500 dilution.)
NCBI and Uniprot Product Information
NCBI Description
GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]
Uniprot Description
GMD: an enzyme that converts GDP-D-mannose to GDP-4-keto-6-D- deoxymannose. Perticipates in the extravasation of activated lymphocytes.
Protein type: Lyase; EC 4.2.1.47; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - amino sugar and nucleotide sugar
Chromosomal Location of Human Ortholog: 6p25
Cellular Component: cytoplasm
Molecular Function: GDP-mannose 4,6-dehydratase activity
Biological Process: Notch signaling pathway; GDP-mannose metabolic process; 'de novo' GDP-L-fucose biosynthetic process
Research Articles on GMDS
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Product Notes
The GMDS gmds (Catalog #AAA9406714) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GDP-mannose 4,6-dehydratase antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GDP-mannose 4,6-dehydratase can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC). Western blotting: 1:500-1:3000 Immunohistochemistry: 1:50-1:500. Researchers should empirically determine the suitability of the GMDS gmds for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GDP-mannose 4,6-dehydratase, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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