Rabbit anti-Human, Mouse GMDS Polyclonal Antibody | anti-GMDS antibody

GMDS (GDP-mannose 4,6 Dehydratase, GDP-D-mannose Dehydratase, GMD) (AP)

Cat. Num. AAA6379978

• Gene Names: GMDS; GMD; SDR3E1
• Reactivity: Human, Mouse
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: GMDS; Polyclonal Antibody; GMDS (GDP-mannose 4; 6 Dehydratase; GDP-D-mannose Dehydratase; GMD) (AP); anti-GMDS antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Isotype: IgG
• Specificity: Recognizes human GMDS. Species Crossreactivity: mouse.
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).

• Applicable Applications for anti-GMDS antibody: Western Blot (WB)
• Application Notes: Applications are based on unconjugated antibody.
• Immunogen: Full length human GMDS, aa1-372 (NP_001491.1).
• Immunogen Sequence: MAHAPARCPSARGSGDGEMGKPRNVALITGITGQDGSYLAEFLLEKGYEVHGIVRRSSSFNTGRIEHLYKNPQAHIEGNMKLHYGDLTDSTCLVKIINEVKPTEIYNLGAQSHVKISFDLAEYTADVDGVGTLRLLDAVKTCGLINSVKFYQASTSELYGKVQEIPQKETTPFYPRSPYGAAKLYAYWIVVNFREAYNLFAVNGILFNHESPRRGANFVTRKISRSVAKIYLGQLECFSLGNLDAKRDWGHAKDYVEAMWLMLQNDEPEDFVIATGEVHSVREFVEKSFLHIGKTIVWEGKNENEVGRCKETGKVHVTVDLKYYRPTEVDFLQGDCTKAKQKLNWKPRVAFDELVREMVHADVELMRTNPNA
• Conjugate: AP
• Note: Preservative Free
• Preparation and Storage: Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Western Blot (WB)

(GMDS rabbit polyclonal antibody. Western Blot analysis of GMDS expression in mouse liver.)

Western Blot (WB)

(Western Blot analysis of GMDS expression in transfected 293T cell line by GMDS polyclonal antibody. Lane 1: GMDS transfected lysate (41.9kD). Lane 2: Non-transfected lysate.)

Related Product Information for anti-GMDS antibody

GMDS, belongs to the GDP-mannose 4,6-dehydratase family. This protein utilizes NADP as a cofactor to catalyze the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose. Mutations in the gene encoding GMDS are involved in resistance to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis.

Product Categories/Family for anti-GMDS antibody

Antibodies; Proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4504031
• NCBI GeneID: 2762
• NCBI Accession #: NP_001491.1
• NCBI GenBank Nucleotide #: NM_001500.2
• UniProt Accession #: O60547; O75357; Q5T954; Q6FH09; Q9UGZ3; Q9UJK9; E9PI88
• Molecular Weight: 39,054 Da
• NCBI Official Full Name: GDP-mannose 4,6 dehydratase isoform 1
• NCBI Official Synonym Full Names: GDP-mannose 4,6-dehydratase
• NCBI Official Symbol: GMDS
• NCBI Official Synonym Symbols: GMD; SDR3E1
• NCBI Protein Information: GDP-mannose 4,6 dehydratase
• UniProt Protein Name: GDP-mannose 4,6 dehydratase
• UniProt Gene Name: GMDS
• UniProt Synonym Gene Names: GMD
• UniProt Entry Name: GMDS_HUMAN

NCBI Description

GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).[supplied by OMIM, Aug 2009]

Uniprot Description

GMD: an enzyme that converts GDP-D-mannose to GDP-4-keto-6-D- deoxymannose. Perticipates in the extravasation of activated lymphocytes.

Protein type: Lyase; Carbohydrate Metabolism - fructose and mannose; EC 4.2.1.47; Carbohydrate Metabolism - amino sugar and nucleotide sugar

Chromosomal Location of Human Ortholog: 6p25

Cellular Component: cytoplasm

Molecular Function: GDP-mannose 4,6-dehydratase activity

Biological Process: Notch signaling pathway; GDP-mannose metabolic process; 'de novo' GDP-L-fucose biosynthetic process