Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using GCN1L1 antibody.)
Rabbit anti-Human GCN1L1 Polyclonal Antibody | anti-GCN1L1 antibody
GCN1L1 Polyclonal Antibody
Gene Names
GCN1; GCN1L; GCN1L1; PRIC295
Reactivity
Human
Applications
Western Blot
Purity
Affinity Purification
Synonyms
GCN1L1; Polyclonal Antibody; GCN1L1 Polyclonal Antibody; eIF-2-alpha kinase activator GCN1; GCN1 (general control of amino acid synthesis yeast homolog) like; GCN1 (general control of amino acid synthesis 1 yeast) like 1; GCN1; GCN1 eIF-2-alpha kinase activator homolog; GCN1 general control of amino acid synthesis 1 like 1; GCN1 general control of amino acid synthesis 1 like 1 (yeast); GCN1 like protein 1; GCN1-like protein 1; GCN1L; General control of amino-acid synthesis 1-like protein 1; HsGCN1; Translational activator gcn1; anti-GCN1L1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Affinity Purification
Form/Format
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration
1 mg/mL (varies by lot)
Sequence Length
2,671
Applicable Applications for anti-GCN1L1 antibody
Western Blot (WB)
Application Notes
WB: 1:500-1:2000
Immunogen
Recombinant protein of human GCN1L1
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using GCN1L1 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using GCN1L1 antibody.)
Product Categories/Family for anti-GCN1L1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
Calculated: 292kDa
Observed: 293kDa
Observed: 293kDa
NCBI Official Full Name
eIF-2-alpha kinase activator GCN1
NCBI Official Synonym Full Names
GCN1, eIF2 alpha kinase activator homolog
NCBI Official Symbol
GCN1
NCBI Official Synonym Symbols
GCN1L; GCN1L1; PRIC295
NCBI Protein Information
eIF-2-alpha kinase activator GCN1
UniProt Protein Name
eIF-2-alpha kinase activator GCN1
UniProt Gene Name
GCN1
UniProt Synonym Gene Names
GCN1L1By similarityManual assertion inferred from sequence similarity toiUniProtKB:E9PVA8Â (GCN1_MOUSE); KIAA0219; HsGCN1
Uniprot Description
Acts as a positive activator of the EIF2AK4/GCN2 protein kinase activity in response to amino acid starvation. Forms a complex with EIF2AK4/GCN2 on translating ribosomes; during this process, GCN1 seems to act as a chaperone to facilitate delivery of uncharged tRNAs that enter the A site of ribosomes to the tRNA-binding domain of EIF2AK4/GCN2, and hence stimulating EIF2AK4/GCN2 kinase activity. Participates in the repression of global protein synthesis and in gene-specific mRNA translation activation, such as the transcriptional activator ATF4, by promoting the EIF2AK4/GCN2-mediated phosphorylation of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52', and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion.
Research Articles on GCN1L1
Similar Products
Product Notes
The GCN1L1 gcn1 (Catalog #AAA2554817) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GCN1L1 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GCN1L1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500-1:2000. Researchers should empirically determine the suitability of the GCN1L1 gcn1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GCN1L1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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