Rabbit anti-Human, Mouse GB5 / GNB5 Polyclonal Antibody | anti-GB5 antibody

Rabbit Polyclonal

Cat. Num. AAA240292

• Gene Names: GNB5; GB5
• Reactivity: Human, Mouse
• Applications: Immunohistochemistry, Western Blot
• Purity: Ammonium sulfate precipitation
• Synonyms: GB5 / GNB5; Polyclonal Antibody; Rabbit Polyclonal; Anti-GB5 / GNB5 Antibody IHC-plus; GNB5; G protein; beta-5 subunit; Gbeta5; beta subunit 5L; Transducin beta chain 5; GB5; anti-GB5 antibody

• Host: Rabbit
• Reactivity: Human, Mouse
• Clonality: Polyclonal
• Specificity: Peptide from the D1 blade of GNB5 protein.
• Purity/Purification: Ammonium sulfate precipitation
• Form/Format: PBS, 0.08% sodium azide.
• Concentration: 1 mg/ml (varies by lot)
• Sequence Length: 353

• Applicable Applications for anti-GB5 antibody: Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
• Application Notes: IHC-P (20 ug/ml), WB; Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
• Immunogen Description: Synthetic peptide from human GNB5 (TFDKNENMAAKKK)
• Immunogen Type: Synthetic peptide
• Preparation and Storage: +4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC)

(Anti-GNB5 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 20 ug/ml.)

Western Blot (WB)

(Western blot of G 5 antibody on 20 ng (1) and 10 ng (2) purified G 5 protein.)

NCBI and Uniprot Product Information

• NCBI GI #: 5729852
• NCBI GeneID: 10681
• NCBI Accession #: NP_006569.1
• NCBI GenBank Nucleotide #: NM_006578.3
• UniProt Accession #: O14775; Q9HAU9; Q9UFT3; B2RBR5
• Molecular Weight: 31,247 Da
• NCBI Official Full Name: guanine nucleotide-binding protein subunit beta-5 isoform a
• NCBI Official Synonym Full Names: guanine nucleotide binding protein (G protein), beta 5
• NCBI Official Symbol: GNB5
• NCBI Official Synonym Symbols: GB5
• NCBI Protein Information: guanine nucleotide-binding protein subunit beta-5; gbeta5; transducin beta chain 5; G protein, beta-5 subunit; G protein, beta subunit 5L; guanine nucleotide-binding protein, beta subunit 5L
• UniProt Protein Name: Guanine nucleotide-binding protein subunit beta-5
• UniProt Gene Name: GNB5
• UniProt Entry Name: GBB5_HUMAN

NCBI Description

Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]

Uniprot Description

G-beta 5: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction. Belongs to the WD repeat G protein beta family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein, heterotrimeric beta

Chromosomal Location of Human Ortholog: 15q21.2

Cellular Component: plasma membrane; nucleus

Molecular Function: G-protein gamma-subunit binding; GTPase activity; protein binding; signal transducer activity; chaperone binding

Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; metabolic process; signal transduction