Rabbit anti-Human GATA5 Polyclonal Antibody | anti-GATA5 antibody

GATA5 Antibody

Cat. Num. AAA9408922

• Gene Names: GATA5; GATAS; bB379O24.1
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Antigen affinity purification.
• Synonyms: GATA5; Polyclonal Antibody; GATA5 Antibody; GATAS; bB379O24.1; anti-GATA5 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Specificity: The antibody detects endogenous levels of total GATA5 protein.
• Purity/Purification: Antigen affinity purification.
• Form/Format: Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
• Concentration: 3 mg/ml (varies by lot)
• Sequence Length: 397

• Applicable Applications for anti-GATA5 antibody: Immunohistochemistry (IHC)
• Application Notes: Immunohistochemistry: 1:50-1:200
• Immunogen Type: Peptide
• Immunogen Description: Synthetic peptide corresponding to a region derived from internal residues of human GATA binding protein 5
• Target Name: GATA5
• Preparation and Storage: Store at -20 degree C

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human gastric cancer tissue using at dilution 1/50.)

Immunohistochemistry (IHC)

(Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue using at dilution 1/50.)

Related Product Information for anti-GATA5 antibody

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity.

Product Categories/Family for anti-GATA5 antibody

Total protein Ab

NCBI and Uniprot Product Information

• NCBI GI #: 17998698
• NCBI GeneID: 140628
• NCBI Accession #: NP_536721.1
• NCBI GenBank Nucleotide #: NM_080473.4
• UniProt Accession #: Q9BWX5; Q17RE2; Q86VU4; D9ZGF7
• Molecular Weight: 41,299 Da
• NCBI Official Full Name: transcription factor GATA-5
• NCBI Official Synonym Full Names: GATA binding protein 5
• NCBI Official Symbol: GATA5
• NCBI Official Synonym Symbols: GATAS; bB379O24.1
• NCBI Protein Information: transcription factor GATA-5
• UniProt Protein Name: Transcription factor GATA-5
• Protein Family: GATA transcription factor
• UniProt Gene Name: GATA5
• UniProt Entry Name: GATA5_HUMAN

NCBI Description

The protein encoded by this gene is a transcription factor that contains two GATA-type zinc fingers. The encoded protein is known to bind to hepatocyte nuclear factor-1alpha (HNF-1alpha), and this interaction is essential for cooperative activation of the intestinal lactase-phlorizin hydrolase promoter. In other organisms, similar proteins may be involved in the establishment of cardiac smooth muscle cell diversity. [provided by RefSeq, Jul 2008]

Uniprot Description

GATA5: Binds to the functionally important CEF-1 nuclear protein binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer. May play an important role in the transcriptional program(s) that underlies smooth muscle cell diversity. Rare variants in GATA5 may be a cause of susceptibility to atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.

Chromosomal Location of Human Ortholog: 20q13.33

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; zinc ion binding; transcription factor activity

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; blood coagulation