Western Blot (WB)
(Anti-GATA2 antibody, MBS176179, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human GATA2, 38.3KD(162aa tag+ M1-G200)Lane 1: Recombinant Human GATA2 Protein 10ngLane 2: Recombinant Human GATA2 Protein 5ngLane 3: Recombinant Human GATA2 Protein 2.5ng )
Rabbit GATA2 Polyclonal Antibody | anti-GATA2 antibody
Anti-GATA2 antibody
Western Blot (WB)
(Anti-GATA2 antibody, MBS176179, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human GATA2, 38.3KD(162aa tag+ M1-G200)Lane 1: Recombinant Human GATA2 Protein 10ngLane 2: Recombinant Human GATA2 Protein 5ngLane 3: Recombinant Human GATA2 Protein 2.5ng )
Western Blot (WB)
(Anti-GATA2 antibody, MBS176179, Western blottingRecombinant Protein Detection Source: E.coli derived -recombinant Human GATA2, 38.3KD(162aa tag+ M1-G200)Lane 1: Recombinant Human GATA2 Protein 10ngLane 2: Recombinant Human GATA2 Protein 5ngLane 3: Recombinant Human GATA2 Protein 2.5ng )
Background: GATA2(GATA binding protein 2) is a human gene which makes a protein called GATA binding protein 2 - a transcription factor. The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. Ciciotte et al.(1997)mapped the mouse Gata2 gene to chromosome 6 by study of DNA from an interspecific backcross panel. They pointed out that the human gene had been mapped to chromosome 3 by Dorfman et al.(1992) using DNA from a panel of 12 rodent/human hybrids containing various human chromosomes and applying Southern blot analysis. By exon trapping using a PAC contig spanning a breakpoint region associated with myeloid leukemia, Wieser et al.(2000) mapped the GATA2 gene to chromosome 3q21. GATA2 is transcribed from telomere to centromere. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Uniprot Description
GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Transcription factor
Chromosomal Location of Human Ortholog: 3q21.3
Cellular Component: nucleoplasm; protein complex
Molecular Function: protein binding; zinc ion binding; chromatin binding; transcription factor binding; transcription factor activity
Biological Process: embryonic placenta development; somatic stem cell maintenance; cell maturation; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; cell differentiation in hindbrain; positive regulation of phagocytosis; positive regulation of megakaryocyte differentiation; central nervous system neuron development; inner ear morphogenesis; transcription, DNA-dependent; positive regulation of erythrocyte differentiation; regulation of histone acetylation; negative regulation of fat cell differentiation; phagocytosis; positive regulation of angiogenesis; negative regulation of macrophage differentiation; commitment of a neuronal cell to a specific type of neuron in the forebrain; ventral spinal cord interneuron differentiation; homeostasis of number of cells within a tissue; pituitary gland development; negative regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; urogenital system development
Disease: Lymphedema, Primary, With Myelodysplasia; Immunodeficiency 21; Myelodysplastic Syndrome
Research Articles on GATA2
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Product Notes
The GATA2 gata2 (Catalog #AAA176179) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-GATA2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's GATA2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the GATA2 gata2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GATA2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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