Immunofluorescence (IF)
(GATA-6 antibody (pAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with GATA-6 antibody at a 1:2,000 dilution.)
Rabbit anti-Human GATA-6 Polyclonal Antibody | anti-GATA-6 antibody
GATA-6 antibody (pAb)
ICC/IF: 1:2,000 dilution
WB: 1:500 dilution
Immunofluorescence (IF)
(GATA-6 antibody (pAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with GATA-6 antibody at a 1:2,000 dilution.)
Immunofluorescence (IF)
(GATA-6 antibody (pAb) tested by immunofluorescence. Formaldehyde fixed HeLa cells stained with GATA-6 antibody at a 1:2,000 dilution.)
Western Blot (WB)
(GATA-6 antibody (pAb) tested by Western blot. Nuclear extract (20 ug) of SW48 cells probed with GATA-6 antibody at a dilution of 1:500.)
Western Blot (WB)
(GATA-6 antibody (pAb) tested by Western blot. Nuclear extract (20 ug) of SW48 cells probed with GATA-6 antibody at a dilution of 1:500.)
Background: GATA-6 (GATA binding factor 6) is a Zn-finger DNA binding transcription factor that is required for the expression of genes regulating formation of the primitive endoderm lineage. GATA-6, along with GATA-4, is a marker of extraembryonic endoderm.
NCBI and Uniprot Product Information
NCBI Description
This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]
Uniprot Description
GATA6: Transcriptional activator that regulates SEMA3C and PLXNA2. Thought to be important for regulating terminal differentiation and/or proliferation. Interacts with LMCD1. Expressed in heart, gut and gut-derived tissues. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Transcription factor; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q11.1-q11.2
Cellular Component: nucleoplasm; transcription factor complex; nucleus
Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; zinc ion binding; chromatin binding; transcription factor activity; transcription factor binding; protein kinase binding
Biological Process: transcription from RNA polymerase II promoter; response to drug; cardiac muscle hypertrophy; endodermal cell fate determination; organ formation; in utero embryonic development; male gonad development; negative regulation of transcription from RNA polymerase II promoter; liver development; cardiac muscle cell differentiation; negative regulation of transforming growth factor-beta1 production; negative regulation of transforming growth factor-beta2 production; positive regulation of angiogenesis; response to estrogen stimulus; phospholipid metabolic process; positive regulation of cardioblast differentiation; smooth muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; blood coagulation; tube morphogenesis; negative regulation of apoptosis; positive regulation of cardiac muscle cell proliferation
Disease: Conotruncal Heart Malformations; Atrial Septal Defect 9; Heart Defects, Congenital, And Other Congenital Anomalies; Tetralogy Of Fallot; Atrioventricular Septal Defect 5
Research Articles on GATA-6
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Product Notes
The GATA-6 gata6 (Catalog #AAA388741) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GATA-6 antibody (pAb) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GATA-6 can be used in a range of immunoassay formats including, but not limited to, Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB). Applications Validated: ICC/IF: 1:2,000 dilution WB: 1:500 dilution. Researchers should empirically determine the suitability of the GATA-6 gata6 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GATA-6, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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