Western Blot (WB)
(WB Suggested Anti-GALR2 AntibodyTitration: 1.0 ug/mlPositive Control: A549 Whole CellGALR2 is supported by BioGPS gene expression data to be expressed in A549)
Rabbit anti-Horse, Human GALR2 Polyclonal Antibody | anti-GALR2 antibody
GALR2 antibody - C-terminal region
Western Blot (WB)
(WB Suggested Anti-GALR2 AntibodyTitration: 1.0 ug/mlPositive Control: A549 Whole CellGALR2 is supported by BioGPS gene expression data to be expressed in A549)
Western Blot (WB)
(WB Suggested Anti-GALR2 AntibodyTitration: 1.0 ug/mlPositive Control: A549 Whole CellGALR2 is supported by BioGPS gene expression data to be expressed in A549)
Target Description: Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways.
NCBI and Uniprot Product Information
NCBI Description
Galanin is an important neuromodulator present in the brain, gastrointestinal system, and hypothalamopituitary axis. It is a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific membrane receptors that are members of the 7-transmembrane family of G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq), in contrast to GALR1, which communicates its intracellular signal by inhibition of adenylyl cyclase through Gi. However, it has been demonstrated that GALR2 couples efficiently to both the Gq and Gi proteins to simultaneously activate 2 independent signal transduction pathways. [provided by RefSeq, Jul 2008]
Uniprot Description
GALR2: Receptor for the hormone galanin and for GALP. The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). Belongs to the G-protein coupled receptor 1 family.
Protein type: Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1; Membrane protein, integral
Chromosomal Location of Human Ortholog: 17q25.3
Cellular Component: integral to membrane; plasma membrane
Molecular Function: protein binding; peptide hormone binding; galanin receptor activity
Biological Process: multicellular organismal development; negative regulation of adenylate cyclase activity; G-protein signaling, coupled to cAMP nucleotide second messenger; synaptic transmission; elevation of cytosolic calcium ion concentration; cell surface receptor linked signal transduction; learning and/or memory; muscle contraction; neuropeptide signaling pathway; digestion; feeding behavior; positive regulation of transcription from RNA polymerase II promoter; neurite development
Research Articles on GALR2
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Product Notes
The GALR2 galr2 (Catalog #AAA3215213) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GALR2 antibody - C-terminal region reacts with Horse, Human and may cross-react with other species as described in the data sheet. AAA Biotech's GALR2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the GALR2 galr2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Synthetic peptide located within the following region: RGTHSGSVLE RESSDLLHMS EAAGALRPCP GASQPCILEP CPGPSWQGPK. It is sometimes possible for the material contained within the vial of "GALR2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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