Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using GALNT3 antibody.)
Rabbit anti-Human GALNT3 Polyclonal Antibody | anti-GALNT3 antibody
GALNT3 Polyclonal Antibody
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using GALNT3 antibody.)
Western Blot (WB)
(Western blot analysis of extracts of various cell lines, using GALNT3 antibody.)
NCBI and Uniprot Product Information
NCBI Description
This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]
Uniprot Description
GALNT3: an enzyme that catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. A single-pass type II membrane protein that localizes to the Golgi apparatus membrane. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Plays a central role in phosphate homeostasis. Mutations cause cause familial tumoral calcinosis, a severe autosomal recessive metabolic disorder that manifests with hyperphosphatemia and massive calcium deposits in the skin and subcutaneous tissues. Overexpressed in many differentiated carcinomas, suggesting that it may serve as a marker of tumor differentiation. Two alternatively spliced human isoforms have been described.
Protein type: EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase
Chromosomal Location of Human Ortholog: 2q24-q31
Cellular Component: Golgi apparatus; Golgi membrane; membrane; perinuclear region of cytoplasm
Molecular Function: calcium ion binding; manganese ion binding; polypeptide N-acetylgalactosaminyltransferase activity
Biological Process: fibroblast growth factor receptor signaling pathway; O-glycan processing; protein amino acid O-linked glycosylation via serine; protein amino acid O-linked glycosylation via threonine
Disease: Tumoral Calcinosis, Hyperphosphatemic, Familial
Research Articles on GALNT3
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Product Notes
The GALNT3 galnt3 (Catalog #AAA2541254) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The GALNT3 Polyclonal Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's GALNT3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). WB: 1:500 - 1:2000. Researchers should empirically determine the suitability of the GALNT3 galnt3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "GALNT3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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