Rabbit GABAA Receptor d Polyclonal Antibody | anti-GABRD antibody

GABAA Receptor d, N-Terminus

Cat. Num. AAA500057

• Gene Names: Gabrd; GABAA-RD
• Reactivity: Predicted: Mouse, Rat
• Applications: Western Blot
• Purity: Affinity Purified from Pooled Serum
• Synonyms: GABAA Receptor d; Polyclonal Antibody; N-Terminus; anti-GABRD antibody

• Host: Rabbit
• Reactivity: Predicted: Mouse, Rat
• Clonality: Polyclonal
• Purity/Purification: Affinity Purified from Pooled Serum
• Form/Format: 100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol.
• Sequence Length: 449

• Applicable Applications for anti-GABRD antibody: Western Blot (WB)
• Application Notes: WB: 1:1,000
• Immunogen: Fusion protein from the N-terminus of the delta subunit; Immunogen Species
• Purification Note: The antibody is prepared from pooled rabbit serum by affinity purification using a column to which the fusion protein immunogen was coupled.
• Preparation and Storage: Store at -20 degree C

Related Product Information for anti-GABRD antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression and substance abuse. The GABAA-R is a multimeric subunit complex. To date six as, four bs and four gs, plus alternativesplicing variants of some of these subunits, have been identified (Olsen and Tobin,1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for a- and b-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, co-expression of a g-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different a-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). More recently there have been a number of studies demonstrating that the delta-subunit of the receptor may affect subunit assembly (Korpi et al., 2002) and may also confer differential sensitivity to neurosteroids and to ethanol (Wallner et al., 2003; Wohlfarth et al., 2002).

Product Categories/Family for anti-GABRD antibody

GABA Receptors

NCBI and Uniprot Product Information

• NCBI GI #: 8393393
• NCBI GeneID: 29689
• NCBI Accession #: NP_058985.1
• NCBI GenBank Nucleotide #: NM_017289.1
• UniProt Accession #: P18506
• Molecular Weight: ~50 kDa
• NCBI Official Full Name: gamma-aminobutyric acid receptor subunit delta
• NCBI Official Synonym Full Names: gamma-aminobutyric acid type A receptor delta subunit
• NCBI Official Symbol: Gabrd
• NCBI Official Synonym Symbols: GABAA-RD
• NCBI Protein Information: gamma-aminobutyric acid receptor subunit delta
• UniProt Protein Name: Gamma-aminobutyric acid receptor subunit delta
• Protein Family: Gamma-aminobutyric acid receptor
• UniProt Gene Name: Gabrd

NCBI Description

GABA-A receptor subunit that contributes to slow phases of GABA-induced desensitization; plays a role in synaptic transmission [RGD, Feb 2006]

Uniprot Description

GABRD: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Defects in GABRD are the cause of susceptibility to generalized epilepsy with febrile seizures plus type 5 (GEFS+5). Generalized epilepsy with febrile seizures-plus refers to a rare familial condition with incomplete penetrance and large intrafamilial variability. Patients display febrile seizures persisting sometimes beyond the age of 6 years and/or a variety of afebrile seizure types. GEFS+ is a disease combining febrile seizures, generalized seizures often precipitated by fever at age 6 years or more, and partial seizures, with a variable degree of severity. Defects in GABRD are the cause of susceptibility to epilepsy, idiopathic generalized type 10 (EIG10). A disorder characterized by recurring generalized seizures in the absence of detectable brain lesions and/or metabolic abnormalities. Generalized seizures arise diffusely and simultaneously from both hemispheres of the brain. Defects in GABRD are the cause of susceptibility to juvenile myoclonic epilepsy type 7 (EJM7). A subtype of idiopathic generalized epilepsy. Patients have afebrile seizures only, with onset in adolescence (rather than in childhood) and myoclonic jerks which usually occur after awakening and are triggered by sleep deprivation and fatigue. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRD sub-subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q36

Molecular Function: GABA-A receptor activity

Biological Process: synaptic transmission