Rabbit FYVE, RhoGEF and PH domain containing 2 Polyclonal Antibody | anti-FGD2 antibody
Rabbit anti-human FYVE, RhoGEF and PH domain containing 2 polyclonal Antibody
NCBI and Uniprot Product Information
Uniprot Description
FGD2: an endosome and ruffle membrane-associated guanine nucleotide exchange factor (GEF) that activates CDC42, a small G protein of the Rho-subfamily. Interacts with RAB6A bound to GTP. Activates JNK1 via CDC42 but not RAC1. Recruitment to the endosome and ruffle membrane requires the presence of phosphoinositides. Binds to phosphatidylinositol 4,5- bisphosphate, phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4- monophosphate and phosphatidylinositol 3-monophosphate. The FYVE-type zinc-finger is necessary for early endosome localization. Recruitment to endosomal membranes via this domain requires the presence of phosphatidylinositol 3-phosphate or other phosphatidylinositides. The PH domain is necessary for localization to the ruffle membrane. Recruitment to ruffle membrane occurs through binding of phosphoinositides by the PH domain. This domain also contributes to the lipid-binding properties of the protein. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: GEFs, Rac/Rho; GEFs
Chromosomal Location of Human Ortholog: 6p21.2
Cellular Component: ruffle; Golgi apparatus; cytoskeleton; early endosome membrane; lamellipodium; cytoplasm; nucleus; cytosol
Molecular Function: small GTPase binding; Rho guanyl-nucleotide exchange factor activity; metal ion binding; guanyl-nucleotide exchange factor activity
Biological Process: regulation of cell shape; regulation of small GTPase mediated signal transduction; filopodium formation; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; small GTPase mediated signal transduction; cytoskeleton organization and biogenesis; actin cytoskeleton organization and biogenesis; positive regulation of GTPase activity
Research Articles on FGD2
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Product Notes
The FGD2 fgd2 (Catalog #AAA710785) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Rabbit anti-human FYVE, RhoGEF and PH domain containing 2 polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's FYVE, RhoGEF and PH domain containing 2 can be used in a range of immunoassay formats including, but not limited to, ELISA (EIA), Immunohistochemistry (IHC). Researchers should empirically determine the suitability of the FGD2 fgd2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FYVE, RhoGEF and PH domain containing 2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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