Rabbit FXR1 Polyclonal Antibody | anti-FXR1 antibody

Anti-FXR1 Antibody

Cat. Num. AAA415857

• Gene Names: FXR1; FXR1P
• Reactivity: Human, Mouse, Rat
• Applications: ELISA, Western Blot
• Purity: Affinity purified
• Synonyms: FXR1; Polyclonal Antibody; Anti-FXR1 Antibody; anti-FXR1 antibody

• Host: Rabbit
• Reactivity: Human, Mouse, Rat
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Affinity purified
• Form/Format: Liquid
• Concentration: 100ug/100ul (varies by lot)
• Sequence Length: 8475

• Applicable Applications for anti-FXR1 antibody: Peptide ELISA (EIA), Western Blot (WB)
• Application Notes: Peptide ELISA titer: 1:1,000-1:5,000; Western blot analysis: 1:200-500; Optimal dilutions/concentrations should be determined by the end user.
• Storage Buffer: PBS, pH 7.4 with 0.02% Sodium Azide
• Immunogen: a 15 amino acid peptide from near the C terminal residues of human FXR1 protein.
• Preparation and Storage: This product is stable for several weeks at 4 degree C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.

Western Blot (WB)

Related Product Information for anti-FXR1 antibody

This gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

References

(1) Vasudevan,S. and Steitz,J.A. AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2. Cell 128 (6), 1105-1118 (2007).

NCBI and Uniprot Product Information

• NCBI GI #: 298231192
• NCBI GeneID: 8087
• NCBI Accession #: NP_001013456.1
• NCBI GenBank Nucleotide #: NM_001013438
• Molecular Weight: 59,920 Da
• NCBI Official Full Name: Homo sapiens fragile X mental retardation, autosomal homolog 1 (FXR1), transcript variant 2, mRNA
• NCBI Official Synonym Full Names: fragile X mental retardation, autosomal homolog 1
• NCBI Official Symbol: FXR1
• NCBI Official Synonym Symbols: FXR1P
• NCBI Protein Information: fragile X mental retardation syndrome-related protein 1; hFXR1p
• UniProt Protein Name: Fragile X mental retardation syndrome-related protein 1
• Protein Family: Fragile X mental retardation syndrome-related protein
• UniProt Gene Name: FXR1
• UniProt Entry Name: FXR1_HUMAN

NCBI Description

The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Description

FXR1: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1. Expressed in all tissues examined including heart, brain, kidney and testis. Belongs to the FMR1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA-binding; Translation

Chromosomal Location of Human Ortholog: 3q28

Cellular Component: polysome; costamere; membrane; cytoplasm; nucleolus

Molecular Function: mRNA binding; mRNA 3'-UTR binding; RNA binding

Biological Process: muscle development; apoptosis; negative regulation of translation; cell differentiation