Western Blot (WB)
(FXR1 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the FXR1 antibody detected the FXR1 protein (arrow).)
Rabbit FXR1 Polyclonal Antibody | anti-FXR1 antibody
FXR1 Antibody (N-term)
Western Blot (WB)
(FXR1 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the FXR1 antibody detected the FXR1 protein (arrow).)
Western Blot (WB)
(FXR1 Antibody (N-term) western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the FXR1 antibody detected the FXR1 protein (arrow).)
that interacts with the functionally-similar proteins FMR1 and
FXR2. These proteins shuttle between the nucleus and cytoplasm and
associate with polyribosomes, predominantly with the 60S ribosomal
subunit. Three transcript variants encoding different isoforms have
been found for this gene.
Darnell, J.C., et al. Hum. Mol. Genet. 18(17):3164-3177(2009)
Purcell, S.M., et al. Nature 460(7256):748-752(2009)
Davidovic, L., et al. J. Med. Genet. 45(10):679-685(2008)
Vasudevan, S., et al. Cell 128(6):1105-1118(2007)
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Description
FXR1: RNA-binding protein required for embryonic and postnatal development of muscle tissue. May regulate intracellular transport and local translation of certain mRNAs. Interacts with FMR1 and FXR2. Interacts with TDRD3, and with CYFIP2 but not with CYFIP1. Expressed in all tissues examined including heart, brain, kidney and testis. Belongs to the FMR1 family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: RNA-binding; Translation
Chromosomal Location of Human Ortholog: 3q28
Cellular Component: polysome; costamere; membrane; cytoplasm; nucleolus
Molecular Function: mRNA binding; mRNA 3'-UTR binding; RNA binding
Biological Process: muscle development; apoptosis; negative regulation of translation; cell differentiation
Research Articles on FXR1
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Product Notes
The FXR1 fxr1 (Catalog #AAA9212982) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 37-66. The FXR1 Antibody (N-term) reacts with Mouse (Predicted Reactivity: Bovine, Hamster, Rat) and may cross-react with other species as described in the data sheet. AAA Biotech's FXR1 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). WB~~1:1000. Researchers should empirically determine the suitability of the FXR1 fxr1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FXR1, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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