Western Blot (WB)
(FSTL3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FSTL3 antibody detected the FSTL3 protein (arrow).)
Rabbit anti-Human FSTL3 Polyclonal Antibody | anti-FSTL3 antibody
FSTL3 Antibody (C-term)
Western Blot (WB)
(FSTL3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FSTL3 antibody detected the FSTL3 protein (arrow).)
Western Blot (WB)
(FSTL3 Antibody (C-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FSTL3 antibody detected the FSTL3 protein (arrow).)
Immunohistochemistry (IHC)
(FSTL3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FSTL3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
Immunohistochemistry (IHC)
(FSTL3 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human testis tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of FSTL3 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated.)
follistatin-module-protein family. It may have a role in
leukemogenesis.
Thadhani, R., et al. Diabetes Care 33(3):664-669(2010)
Bloise, E., et al. BMC Cancer 9, 320 (2009) :
Stamler, R., et al. J. Biol. Chem. 283(47):32831-32838(2008)
Lara-Pezzi, E., et al. Endocrinology 149(11):5822-5827(2008)
NCBI and Uniprot Product Information
NCBI Description
Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008]
Uniprot Description
FSTL3: Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10. A chromosomal aberration involving FSTL3 is found in a case of B-cell chronic lymphocytic leukemia. Translocation t(11;19)(q13;p13) with CCDN1. 2 isoforms of the human protein are produced by alternative initiation.
Protein type: Secreted; Secreted, signal peptide; Oncoprotein
Chromosomal Location of Human Ortholog: 19p13
Cellular Component: nucleoplasm; Golgi apparatus; extracellular space; extracellular region; nucleus; secretory granule
Molecular Function: protein binding; fibronectin binding; activin binding
Biological Process: regulation of transcription from RNA polymerase II promoter; negative regulation of osteoclast differentiation; negative regulation of activin receptor signaling pathway; ossification; transcription, DNA-dependent; adrenal gland development; male gonad development; positive regulation of cell-cell adhesion; hemopoietic progenitor cell differentiation; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; kidney development; lung development; negative regulation of BMP signaling pathway
Research Articles on FSTL3
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Product Notes
The FSTL3 fstl3 (Catalog #AAA9202407) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 229-258. The FSTL3 Antibody (C-term) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FSTL3 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC). WB~~1:1000. Researchers should empirically determine the suitability of the FSTL3 fstl3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FSTL3, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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