Western Blot (WB)
(Anti- FRZB Picoband antibody, MBS178292, Western blottingAll lanes: Anti FRZB (MBS178292) at 0.5ug/mlLane 1: PANC Whole Cell Lysate at 40ugLane 2: U87 Whole Cell Lysate at 40ugPredicted bind size: 36KDObserved bind size: 36KD )
anti-Human FRZB Polyclonal Antibody | anti-FRZB antibody
Anti-FRZB Antibody
Western Blot Concentration: 0.1-0.5ug/ml
Western Blot (WB)
(Anti- FRZB Picoband antibody, MBS178292, Western blottingAll lanes: Anti FRZB (MBS178292) at 0.5ug/mlLane 1: PANC Whole Cell Lysate at 40ugLane 2: U87 Whole Cell Lysate at 40ugPredicted bind size: 36KDObserved bind size: 36KD )
Western Blot (WB)
(Anti- FRZB Picoband antibody, MBS178292, Western blottingAll lanes: Anti FRZB (MBS178292) at 0.5ug/mlLane 1: PANC Whole Cell Lysate at 40ugLane 2: U87 Whole Cell Lysate at 40ugPredicted bind size: 36KDObserved bind size: 36KD )
Background: FRZB is also known as FRE or OS1. The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. FRZB is a Wnt-binding protein especially important in embryonic development. It is a competitor for the cell-surface G-protein receptor Frizzled. FRZB is localized in the extracellular plasma membrane. Unlike frizzled, frzb lacks the 7 transmembrane domains normally found in G-protein-coupled receptors. It is still considered a homolog of frizzled because it contains a Cysteine Rich Domain (CRD), and because of its intracellular C-terminus which is crucial for signaling.
NCBI and Uniprot Product Information
NCBI Description
The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]
Uniprot Description
FRZB: Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. Defects in FRZB are associated with susceptibility to osteoarthritis type 1(OS1). Osteoarthritis is a degenerative disease of the joints characterized by degradation of the hyaline articular cartilage and remodeling of the subchondral bone with sclerosis. Clinical symptoms include pain and joint stiffness often leading to significant disability and joint replacement. Belongs to the secreted frizzled-related protein (sFRP) family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 2q32.1
Cellular Component: extracellular space; integral to membrane; membrane
Molecular Function: G-protein coupled receptor activity; Wnt receptor activity; Wnt-protein binding
Biological Process: convergent extension involved in organogenesis; G-protein coupled receptor protein signaling pathway; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of Wnt receptor signaling pathway; neural crest cell differentiation; positive regulation of apoptosis; positive regulation of fat cell differentiation; skeletal development
Disease: Osteoarthritis Susceptibility 1
Research Articles on FRZB
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Product Notes
The FRZB frzb (Catalog #AAA178292) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-FRZB Antibody reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's FRZB can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), ELISA (EIA). ELISA Concentration: 0.1-0.5ug/ml Western Blot Concentration: 0.1-0.5ug/ml. Researchers should empirically determine the suitability of the FRZB frzb for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "FRZB, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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