Rabbit anti-Human FRS2 Polyclonal Antibody | anti-FRS2 antibody

FRS2, ID (FRS2, Fibroblast growth factor receptor substrate 2, FGFR-signaling adaptor SNT, Suc1-associated neurotrophic factor target 1) (FITC)

Cat. Num. AAA6300172

• Gene Names: FRS2; SNT; SNT1; FRS2A; SNT-1; FRS2alpha
• Reactivity: Human
• Applications: Western Blot
• Purity: Purified by Protein A Affinity Chromatography.
• Synonyms: FRS2; Polyclonal Antibody; ID (FRS2; Fibroblast growth factor receptor substrate 2; FGFR-signaling adaptor SNT; Suc1-associated neurotrophic factor target 1) (FITC); Suc1-associated neurotrophic factor target 1; anti-FRS2 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Polyclonal
• Isotype: IgG
• Purity/Purification: Purified by Protein A Affinity Chromatography.
• Form/Format: Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein Isothiocyanate (FITC).

• Applicable Applications for anti-FRS2 antibody: Western Blot (WB), FLISA
• Application Notes: WB: 1:100-500; FLISA: 1:1,000; Applications are based on unconjugated antibody.
• Immunogen: FRS2 antibody is generated from rabbits immunized with a KLH conjugated synthetic between 274-303 amino acids selected from the Central region of human FRS2.
• Conjugate: FITC
• Note: Preservative Free
• Special Handling: Light sensitive
• Preparation and Storage: Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Western Blot (WB)

(FRS2 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the FRS2 antibody detected the FRS2 protein (arrow).)

Related Product Information for anti-FRS2 antibody

Adapter protein that links FGR and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Product Categories/Family for anti-FRS2 antibody

Antibodies; Growth Factors; Cytokines

References

Zhou, W., et al. Cell Res. 19(10):1165-1177(2009). Cha, J.Y., et al. J. Biol. Chem. 284(10):6227-6240(2009). Li, M., et al. J. Dermatol. Sci. 53(3):182-191(2009). Turner, S.T., et al. Hypertension 52(2):359-365(2008). Gudbjartsson, D.F., et al. Nat. Genet. 40(5):609-615(2008).

NCBI and Uniprot Product Information

• NCBI GI #: 110347408
• NCBI GeneID: 10818
• NCBI Accession #: NP_006645.3
• NCBI GenBank Nucleotide #: NM_006654.4
• UniProt Accession #: Q8WU20; O43558; Q7LDQ6; B0LPF2; B2R684
• Molecular Weight: 57,029 Da
• NCBI Official Full Name: fibroblast growth factor receptor substrate 2
• NCBI Official Synonym Full Names: fibroblast growth factor receptor substrate 2
• NCBI Official Symbol: FRS2
• NCBI Official Synonym Symbols: SNT; SNT1; FRS2A; SNT-1; FRS2alpha
• NCBI Protein Information: fibroblast growth factor receptor substrate 2; FGFR substrate 2; FGFR signalling adaptor; FGFR-signaling adaptor SNT; suc1-associated neurotrophic factor target 1
• UniProt Protein Name: Fibroblast growth factor receptor substrate 2
• Protein Family: Fibroblast growth factor receptor substrate
• UniProt Gene Name: FRS2
• UniProt Synonym Gene Names: FGFR substrate 2; SNT-1
• UniProt Entry Name: FRS2_HUMAN

Uniprot Description

FRS2: an adaptor protein involved in fibroblast growth factor receptor (FGFR) signaling. Plays an important role in linking FGFR and nerve growth factor receptors with Ras/MAPK signaling pathways.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: membrane; integral to plasma membrane; plasma membrane; intercellular junction; endosome

Molecular Function: protein binding; phosphatase activator activity; neurotrophin TRKA receptor binding; transmembrane receptor protein tyrosine kinase adaptor protein activity; insulin receptor binding; fibroblast growth factor receptor binding

Biological Process: epidermal growth factor receptor signaling pathway; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; activation of MAPK activity; gastrulation with mouth forming second; regulation of epithelial cell proliferation; regulation of apoptosis; G-protein coupled receptor protein signaling pathway; determination of anterior/posterior axis, embryo; induction of an organ; neuroblast proliferation; forebrain development; insulin receptor signaling pathway; innate immune response; optic placode formation involved in camera-type eye; transmembrane receptor protein tyrosine phosphatase signaling pathway